| 严清明,陈瑛,廉南,郭桂凤,牟洪继,赵国良,孙德明,曹均告,麦明琼.柔肝法治疗肝气郁结证溃疡性结肠炎的研究[J].中国中西医结合杂志,1995,(10):579-582 |
| 柔肝法治疗肝气郁结证溃疡性结肠炎的研究 |
| Study on Essence of Liver-Qi Stagnation in Ulcerative Colitis |
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| DOI： |
| 中文关键词: 溃疡性结肠炎 肝气郁结 胃肠冲剂 |
| 英文关键词:ulcerative colitis Stagnation of the Liver-Qi Wei Chang Ning |
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| 摘要点击次数: 1552 |
| 全文下载次数: 934 |
| 中文摘要: |
| 本研究以柔肝为治疗组，健脾为对照组，对肝气郁结在溃疡性结肠炎（ＵＣ）发病学中的内在联系进行了临床及实验研究。结果：治疗组总有效率为９６％，对照组总有效率为８４．４％，两组比较有显著性差异（Ｐ＜０．０５）；Ｅ玫瑰花形成率、淋巴细胞转化率两组较治疗前均有显著增高，对调节植物神经功能的失调率治疗组明显优于对照组（Ｐ＜０．０１）。实验研究观察到大鼠ＵＣ模型肠管Ｐ物质和血管活性肠肽含量：模型组明显增高，治疗组较模型组含量明显降低（Ｐ＜０．０１），与对照组比较有显著性差异（Ｐ＜０．０１）。提示：柔肝药物胃肠宁具有调节神经──内分泌（胃肠激素）──免疫的作用。 |
| 英文摘要: |
| The links between stagnation of the Liver-Qi in the pathogenesis and ulcerative colitis (UC) were clinically and experimentally studied using the principle of nourishing the Liver in treated group and the principle of invigorating the Spleen in control group.The results showed that the effective rate was 96% in treated group and 82% in control group, and the difference was significant (P<0.05); the formation rate of E rosettes and the transformation rate of lymphocytes were significantly raised in the two groups compared with the pre-treatment period,treated group was evidently superior to control group in the rate of dysfunction of autonomous nerve system (P<0.01).The level of intestinal styrenated phenol (SP) and vasoactive intestinal polypeptide (VIP) of UC model were determined in rats. The results showed that the level of SP and VIP significantly increased in UC model group.They markedly lowered in treated group compared with model group (P<0.01) and there was significant difference in comparing with control group (P<0.01). It revealed that Wei Chang Ning,a drug to nourishing the Liver, had the action of regulating neurological-endocrinological (gastrointestinal hormone)-immunological system. |
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