佘万东,陈兆和.川芎嗪对卡那霉素耳中毒影响的实验研究[J].中国中西医结合杂志,1995,(10):609-611 |
川芎嗪对卡那霉素耳中毒影响的实验研究 |
Effect of Ligustrazine on Kanamycin Ototoxicity |
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DOI: |
中文关键词: 川芎嗪 超氧化物歧化酶 耳蜗 卡那霉素 丙二醛 |
英文关键词:Ligustrazine superoxide dismutase Cochlea Kanamycin malondialdehyde |
基金项目:江苏省中医管理局资助 |
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中文摘要: |
通过检测豚鼠耳蜗组织超氧化物歧化酶(SOD)、丙二醛(MDA),结合耳蜗电图和形态学观察,评价川芎嗪(TMP)对卡那霉素(KM)耳中毒的防治作用。结果显示,KM能显著增加SOD活力和MDA含量,使听力下降,TMP能显著降低SOD活力和MDA含量,听力得以改善。推测脂质过氧化反应参与了KM耳中毒过程,TMP通过抗氧化作用减轻KM耳毒性。 |
英文摘要: |
By measuring cochlear superoxide dismutase (SOD) activity, malondialdehyde (MDA) and electrocochleogram (ECoG) in guinea pigs, the antioxidation of Ligustrazine on Kanamycin (KM) was studied. The results showed that SOD activity, MDA content and threshold value of ECoG were significantly increased after KM was adininistered, while it markedly reduced after Ligustrazine was given. It was considered that lipid hyperoxidative reaction was correlated with KM ototoxicity,Ligustrazine could prevent and treat KM ototoxicity by antioxidation. |
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