针灸对移植性乳腺癌小鼠免疫功能及病理组织学的影响

作者	单位
刘丽军	白求恩国际和平医院
郭诚杰	陕西中医学院
焦新民	陕西中医学院
殷克敬	陕西中医学院
李炎高	白求恩国际和平医院

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中文摘要:

本实验主要观察了针灸对移植性乳腺癌小鼠免疫功能及病理组织学的影响。结果发现：针灸组ＮＫ细胞活性、Ｔ淋巴细胞α－醋酸萘酯酶（ＡＮＡＥ）阳性率、淋巴细胞转化率均明显增高，与对照组比较，有非常显著性差异（Ｐ＜０．０１），而与正常组比较无显著性差异（Ｐ＞０．０５）。病理切片中，组织学分级针灸组与对照组比较有非常显著性差异（Ｐ＜０．０１），腺样结构、淋巴细胞浸润程度针灸组与对照组比较，差异显著（Ｐ＜０．０５）。针灸组肿瘤体积明显小于对照组（Ｐ＜０．０１），说明针灸可以提高乳腺癌小鼠的免疫功能，抑制乳腺癌之增长，提高乳腺癌细胞的分化程度和淋巴细胞浸润程度。

英文摘要:

This experiment mainly describes the effects of acupuncture on immunologic function and histopathology of transplanted mammary cancer in mice. The results were as follows: in acupuncture group,NK cell activity and T-lymphocyte positive rate of acid α-naphthyl acetate esterase (ANAE) and lymphocyte transformation rate were all increased. Compared with the control group,there was a significant difference (P<0.01). The difference was insignificant, when compared with normal group (P>0.05). Comparing the pathology grading of acupuncture group with control group, it showed marked difference in pathological section (P<0.01). Adenoid structure and the degree of lymphocytic infiltration also have marked difference between acupuncture and control group (p<0. 05). Less tumour volume in acupuncture than control group were observed (P<0. 01).This indicated that acupuncture might increase the immunologic function of transplanted mammary cancer in mice and inhibit the growth of mammary cancer and enhance both differentiation level of mammary cancer cells and lymphocytic infiltration. Possibly acupuncture mightt reduce the malignancy of mammary cancer cells.

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