补肾活血片对Ⅱ型糖尿病患者过氧化脂质、血脂及血糖的影响

本研究观察了补肾活血片对气阴两虚、肾虚血瘀Ⅱ型糖尿病患者血清过氧化脂质（ＬＰＯ）、血脂及血糖的影响，并设有对照组。结果：糖尿病患者ＬＰＯ含量高于健康对照组（Ｐ＜０．０５）。糖尿病合并血管病变，或血糖控制不好时，ＬＰＯ含量升高更为明显（ｐ＜０．０１，Ｐ＜０．０５），与甘油三酯（ＴＧ）呈正相关（ｒ＝０．２５，Ｐ＜０．０５）。治疗组服用补肾活血片后ＬＰＯ含量降低（Ｐ＜０．０５），高密度脂蛋白（ＨＤＬ－Ｃ）升高（Ｐ＜０．０５），血糖下降（ｐ＜０．０５），对照组无明显变化。提示糖尿病患者体内ＬＰＯ反应增加，血糖控制不佳、合并血管病变时，ＬＰＯ增加更为显著。补肾活血片有一定的降低ＬＰＯ、血糖及提高清除胆固醇的能力。

英文摘要:

Sixty-eight patients suffering from diabetes mellitus(DM) type Ⅱ with Kidney Deficiency and blood stasis were enrolled and divided randomly into treatment group(34 cases)and placebo group(34 healthy subjects).The amount of serum lipid peroxide(LPO),blood lipid and blood sugar was determined.The results showed that the serum LPO in treatment group was higher than that in placebo group.The serum LPO increased significantly in DM patients with vascular disease or with uncontrolled blood sugar.The serum LPO was positively correlated with triglyceride(TG).After using Bushenliuoxue Tablet(BSHX) serum LPO lowered,blood sugar decreased and high density lipoprotein-cholesterol (HDL-C) increased in treatment group,but in placebo group these three parameters were not changed significantly.These results indicated that LPO reaction in type Ⅱ DM patients increased.The higher the blood sugar and TG or complicated with vascular disease,the LPO reaction enhanced markedly.BSHX tablets have the function of reducing the serum LPO and blood sugar,clearing cholesterol.Therefore,this tablet will have a good prospect in the prevention and treatment for DM patients complicated with vascular disease.

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