中西医结合治疗对肝豆状核变性患者智商影响的前瞻性研究

Perspective Study on Intelligence Quotient of 28 Hepatic Lenticular Degeneration Patients with Treatment Combining Traditional Chinese and Western Medicine

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DOI：

中文关键词: 肝豆状核变性智商肝豆汤

英文关键词:篽epatic lenticular degeneration intelligence quotient HLD-relief decoction

基金项目:

作者	单位
蔡永亮	安徽中医学院神经病学研究所
杨任民	安徽中医学院神经病学研究所
许圣弘	安徽中医学院神经病学研究所
李凯	安徽中医学院神经病学研究所

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中文摘要:

２８例肝豆状核变性（ＨＬＤ）患者治疗前与中药肝豆汤配合西药驱铜治疗２个月后，分别应用韦氏成人智力量表（ＷＡＩＳ－ＲＣ）测定，对其智商变化进行对比观察，并选３０例为健康对照组。结果表明ＨＬＤ患者言语智商（ＶＩＱ）、操作智商（ＰＩＱ）及全量表智商（ＦＩＱ）较对照组普遍显著降低（Ｐ均＜０．００５），尤以视空间障碍更为突出，证明铜离子在ＨＬＤ脑内沉积不仅损害神经运动功能且严重损害智能。经中西医结合治疗后总体智力水平显著提高（ＶＩＱ、ＰＩＱ、ＦＩＱ的Ｐ值均＜０．００１），其中以ＰＩＱ各项分测验得分提高尤为突出（Ｐ均＜０．００１），说明治疗后ＨＬＤ的智力与锥体外系症状同样有效。本研究还提示ＨＬＤ的病程越长，智力损害的程度越严重，及早治疗则智商水平的恢复更易接近正常标准。

英文摘要:

Intelligence quotient (IQ) of 28 hepatic lenticular degeneration (HLD) patients was analysed with Wechsler Adult intelligence Scale-revised by China (WAISRC) before and after two months treatment by the HLD-Relief decoction supplemented with copper-clearing drug, and the result was compared with that of 30 healthy persons for control. The results showed that the Vocable IQ (VIQ) , Performance IQ(PIQ) and Full IQ(FIQ) of HLD patients were markedly lower than that of control (P＜ 0 . 005) , especially in visual space disorder,which indicated that the copper ion deposit ing in patient’s brain not only damaged neuronic motorial functions but also produced a marked effect on the patient’s intelligence.After treatment, the total intelligential level including VIQ, PIQ and FIQ has been raised, particularly in PIQ in which all scores were obviously increased (P＜0. 001) .It was also showed that the damage of intelligence in HLD patient became more serious as the course of disease was prolonged and the early treatment facilitated the IQ level to approach the normal criterion. It indicated that the treatment with combined therapy is effective to the intelligence and extrapyramidal symptoms in HLD patients.

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