陈群,陈南菊,王胜春.黄连对大肠杆菌R质粒消除作用的实验研究[J].中国中西医结合杂志,1996,(1):37-38 |
黄连对大肠杆菌R质粒消除作用的实验研究 |
Experimental Study of R Plasmid Eliminating Action of Coptis Chinensis on E. Coli |
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DOI: |
中文关键词: 黄连 大肠杆菌 R质粒 消除 |
英文关键词:Coptis chinensis E.coli R plasmid elimination |
基金项目:广东省高教厅资助 |
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中文摘要: |
本研究以中药黄连的提取物为质粒消除剂,用携带R质粒的多重耐药性大肠杆菌E.102株为靶细菌,进行了体外R质粒消除作用的实验研究。同时观察了黄连作用不同时间,对大肠杆菌R质粒消除作用的影响。实验结果表明:黄连具有消除R质粒的作用。经黄连作用24h,消除率为2.42%,延长作用时间至48h,其消除率提高为22.57%。细菌丢失的耐药性可以表现为单一或两种耐药性的丧失。 |
英文摘要: |
The R plasmid curing experiment was performed in vitro with E.coli strain E. 102 bearing R plasmid as target bacteria and Coptis chinensis as elimination agent. The influence of different time on R plasmid elimination was also observed. Results showed that when the acting time was 24 hours, the cure rate of R plasmid was 2 . 42% and when the acting time increased to 48 hours, the cure rate elevated to 22 . 57%. The Missing patterns of R plasmid might be occurred in disappearence of either multiple or single resistance. |
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