益气活血方药对左室舒张功能的临床观察

用多普勒超声心动图和左室阻抗微分图对５２例老年人心舒张功能不全患者观察口服益气活血方药（补气强心汤）前后，左室舒张功能、心功能级别及心气虚虚损程度的比较。并与同年龄组随机取样以维拉帕米治疗的１５例进行对照。结果显示左室舒张功能不全患者几乎均有心气虚证（９２．３％），并多兼有血瘀证（６９．２％）。经中药治疗后有心功能级别的提高（８２．６％）及心气虚虚损程度的改善（８９．６％）。多普勒超声检测，反映左室舒缓性能的参数均有不同程度的改善（Ｐ＜０．０５或０．０１），但反映左室顺应性能的参数则无明显改善（Ｐ＞０．０５）。益气活血方药对左室功能不全的作用机制除对原发病因的控制外还可能与中药的钙拮抗效应有关。

英文摘要:

The left ventricular diastolic function,grade of heart function and degree of Heart-Qi Deficiency of 52 aged patients with left ventricular diastolic dysfunction(LVDD)were measured by means of Doppler echocardiography and left ventricular impedance cardiography before and after treatment with Buqi Qiangxin decoction(BQQXD),a recipe of TCM for reinforcing Qi and promoting blood circulation. The data were compared with that of control group(15 cases)treated with verapamil. Results showed that 92.3% of the LVDD patients were associated with Heart-Qi Deficiency and 69.2% were complicated with blood stasis.After treated with BQQXD,the grade of heart function was elevated in 82.6%,the degree of Heart-Qi Deficiency was improved in 89.6% of the patients.The parameters reflecting the left ventricular diastolic function were all improved in different degree(P<0.05～0.01),but the parameters reflecting left ventricular compliance were changed insignificantly(P>0.05).It indicated that besides controlling on the etiological factors,the mechanism of BQQXD in treating left ventricular dysfunction might be related with its calcium antagonistic effect.

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