愈疡散治疗消化性溃疡的临床与实验研究

用中药愈疡散与西咪替丁对照，对经纤维胃镜证实的消化性溃疡（ＰＵ）２００例患者进行临床观察。结果愈疡散对ＰＵ治愈率为８８．１％，总有效率为９６．０％，与西咪替丁疗效相似，而复发率治疗组（１９．１％）与对照组（４６．４％）比较差别非常显著（Ｐ＜０．０１）。动物实验表明：高剂量愈疡散对实验性胃溃疡和胃炎的胃粘膜的保护作用明显优于西咪替丁，而兼有增强胃粘膜“保护因子”与削弱胃粘膜“攻击因子”的双重作用，急性毒性实验证明愈疡散无任何毒性作用。

英文摘要:

Two hundreds patients of peptic ulcer diagnosed by fiber-gastroscope treated with Yuyang powder(YYP)was observed and compared with patient treated with cimetidine for control.Results showed that the curative rate of YYP on peptic ulcer was 88.1%,the total effective rate was 96%,similar to that of cimetidine. But the difference of recurrence rate(19.1% for YYP and 46% for control)between the two groups was very significant.Animal experiment revealed that the protective action of YYP with high dosis on gastric mucosa in peptic ulcer and gastritis was superior to that of cimetidine,its has the double effect of both strengthening protective factors and weakening aggressive factors of gastric mucosa.Acute toxicologic test indicated that YYP has no toxic effect and was safe in clinical practice.

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