张海男,黎杏群,李学文.清肝泻火汤对内毒素诱发家兔肝火证的疗效和机理[J].中国中西医结合杂志,1996,(2):95-98 |
清肝泻火汤对内毒素诱发家兔肝火证的疗效和机理 |
Study on the Effect and Mechanism of Qinggan Xiehuo Decoction in Treatment of Endotoxininduced Uveitis of Rabbits |
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DOI: |
中文关键词: 清肝泻火汤 肝火证 内毒素 虹膜睫状体炎 |
英文关键词:Qinggan Xiehuo Decoction live fire zheng endotoxin iridocyclitis |
基金项目:国家自然科学基金 |
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中文摘要: |
采用内毒素诱发家兔肝火证模型,观察了清肝泻火汤的疗效。实验结果表明该方具有以下作用:(1)减轻肝火证临床症状,如皮肤温度、饮水量、呼吸、尿量、易怒、心率等明显缓解(P<0.05或P<0.01);(2)改善眼部症状,裂隙灯下虹膜充血与房水混浊均显著好转(P<0.01);(3)减少房水炎性渗出,房水白细胞数与蛋白含量明显降低(P<0.01)。(4)降低血液和房水中炎症介质的浓度(P<0.01,P<0.05)。(5)病理形态学表明,该方具有保护毛细血管和血-房水屏障,减轻眼葡萄膜组织病理损害的作用。 |
英文摘要: |
The therapeutic efficacy of Qinggan Xiehuo Decoction (QGXHD)on rabbit model of uveitis induced by endotoxin(EIU)was observed and compared with the control.Results showed that:(1)The symptoms of Liver-Fire such as conjunctival congestion,thirsty dark urine, oliguria,irritability and rapid pulse were markedly relieved(p<0.05~0.01);(2)The ophthalmic signs, iris hyperemia and aqueous humor turbidity observed through slit-lamp were improved significantly(P<0.01);(3)The inflammatory infiltration, the protein content and leukocyte count in the aqueous humor decreased markedly(p<0.01);(4)The concentration of inflammatory mediators in blood and aqueous humor were reduced.(5)Pathological examination showed that the QGXHD could protect the capillary,blood-aqueous barrier and alleviated the uveal damage caused by endotoxin. |
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