补肾中药对拟痴呆小鼠胆碱能M－受体功能及胆碱酯酶活性的影响

作者	单位
莫启忠	上海中医药大学核医学研究室
马骏	上海中医药大学核医学研究室
宫斌	上海中医药大学核医学研究室
宁炼	上海中医药大学核医学研究室
王宝妹	上海中医药大学核医学研究室

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中文摘要:

选用氯化铝溶液制备拟痴呆小鼠动物模型，研究补肾中药对拟痴呆小鼠大脑皮层组织（Ｃｅｒ）中胆碱能Ｍ－受体结合容量（Ｒｔ）和胆碱酯酶（ＡｃｈＥ）活性的影响。结果表明，拟痴呆小鼠Ｃｅｒ中ＡｃｈＥ活性比正常青年小鼠明显提高（Ｐ＜０．０１），而Ｍ－受体Ｒｔ值显著降低（Ｐ＜０．００１）。补肾中药可明显降低拟痴呆小鼠Ｃｅｒ中ＡｃｈＥ，活性（Ｐ＜０．０５～０．０１），增加Ｍ－受体Ｒｔ值（Ｐ＜０．００１）。提示补肾中药能通过降低拟痴呆小鼠Ｃｅｒ中ＡｃｈＥ活性，增加Ｍ－受体Ｒｔ值，明显提高记忆能力。补肾中药有防治脑功能减退和防治早老性痴呆的作用。

英文摘要:

Dementia mimetic mouse model was formed with aluminum chloride solution in order to study the effect of Chinese herbal medicine of tonifying Kidney(TK)on the M-cholinergic receptor(Rt)and the acetylcholinesterase(AchE) activity in the model’s cerebral cortex.Results showed that the M-cholinergic receptor Rt lowered and the AchE increased in the model evidently as compared with the healthy young mice.The TK could markedly reduce the increased AchE and elevate the lowered M-cholinergic receptor Rt in cerebral cortex of the dementia mimetic mice,it also could improve the memory.These results suggested that TK is effective in preventing the degeneration of cerebral function and presenile dementia.

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