| 吴铁,廖进民,李青南,黄莲芳,张志平,崔燎.壮骨肾宝防治肾上腺皮质激素所致大鼠骨质疏松的实验研究[J].中国中西医结合杂志,1996,(2):102-104 |
| 壮骨肾宝防治肾上腺皮质激素所致大鼠骨质疏松的实验研究 |
| Experimental Study on Zhuanggu Shengbao in Preventing Hormone-Induced Osteoporosis of Rats |
| 免费下载全文 查看/发表评论 下载PDF阅读器 |
| |
| DOI： |
| 中文关键词: 醋酸泼尼松 骨质疏松 骨小梁 骨计量学 壮骨肾宝 |
| 英文关键词:prednisone acetate osteoporosis trabecula Zhanggu Shenbao bone histomorphometry |
| 基金项目:国家自然科学基金 |
|
| 摘要点击次数: 1319 |
| 全文下载次数: 1234 |
| 中文摘要: |
| 本研究采用３月龄ＳＤ雄性大鼠２４只，随机分为对照组（Ⅰ组）、激素组（Ⅱ组）和预防组（Ⅲ组）。Ⅱ组喂醋酸泼尼松２次／周；Ⅲ组除喂泼尼松外，还同时喂壮骨肾宝。３个月后对３组大鼠胚骨上段的骨片用图像分析仪进行测算和分析。激素组与对照组比较，由于骨吸收大于骨形成，出现骨小梁面积和数量减少，骨小梁之间的空隙增加。出现明显的骨质疏松症状。用壮骨肾宝预防的激素组，骨吸收率受到明显抑制，新骨形成增加，因而骨量明显增加。本研究提示壮骨肾宝能预防激素所致的骨质疏松。 |
| 英文摘要: |
| Twenty four male Sprague-Dawley rats at 3 months of age were divided randomly into 3 groups.Prednisone acetate was given to the group B twice per weeks, Zhuanggu Shengbao(ZGSB)was added to the group C besides prednisone,the group A was control.The histomorphometric parameters of bone slides of proximal tibia were measured and calculated with image pattern analyser after 3 months of medication.Results showed that in comparing with group A,in group B the area and number of trabecula decreased,the intertrabecular space increased due to the bone resorption exceeded the bone formation,and the symptoms of osteoporosis revealed obviously.However,in group C,the bone resorption rate was markedly inhibited, and the formation of new bone accelerated so that the bone mass increased significantly.These results indicated the ZGSB could prevent the osteoporosis induced by prednisone acetate. |
| 关闭 |
扫描微信二维码，获取更多信息