以肝炎Ⅳ号为主治疗慢性活动性肝炎高胆红素血症的临床与实验研究

在应用护肝西药的基础上，以肝炎Ⅳ号治疗慢性活动性肝炎高胆红素血症（ＴＢｉ＞１７１μｍｏｌ／Ｌ）６０例（实验组），与应用护肝西药治疗５６例对照观察，结果显示，在退黄、降酶、升高白蛋白、改善Ａ／Ｇ倒置等方面，实验组明显优于对照组（Ｐ＜０．０５～０．００１）；用肝炎Ⅳ号治疗ＣＣｌ４造成实验性肝损伤的小白鼠，结果显示，肝炎Ⅳ号也能降低血清胆红素（ＴＢｉ）和ＡＬＴ、升高白蛋白，与ＣＣｌ４组比较亦有统计学差异（Ｐ＜０．０５～０．０１）。同时，还能明显增加正常和异常大白鼠的胆汁流量。表明肝炎Ⅳ号有明显利胆、降酶和升高白蛋白、改善Ａ／Ｇ比值的作用。

英文摘要:

Sixty chronic active hepatitis patients complicated with hyperbilirubinemia(total bilirubin>17lμmol/L) were treated with combined treatment of Ganyan Ⅳ and Western medicine.The curative effect was compared with that treated with Western medicine alone as control(56 cases).Result showed that the effect of combined therapy group was much better than that of the control in eliminating the jaundice,descending the alanine transaminase(ALT) and improving the reversed A/G ratio(P<0.05～0.001).In experimental studies,Ganyan Ⅳ was applied to the mice with acute liver damage formed by CCl4,it also showed significant effect on reducing total bilirubin and elevating the serum albumin statistically as compared with control(P<0.05～0.01).In addition Ganyan Ⅳ could accellerating the bile excretion of normal as well as of liver damaged rats significantly.It was concluded that the Ganyan Ⅳ has the effects of treating jaundice,descending transaminase,elevating serum albumin and improving A/G ratio.

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