愈心痛胶囊对急性心肌缺血犬血浆内皮素和血清一氧化氮的影响

作者	单位
雷燕	中国中医研究院西苑医院
刘建勋	中国中医研究院西苑医院
周亚伟	中国中医研究院西苑医院
尚晓泓	中国中医研究院西苑医院
陈可冀	中国中医研究院西苑医院

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中文摘要:

本研究观察了中药复方愈心痛胶囊消化道给药对实验性急性心肌缺血犬血浆内皮素（ＥＴ）和血清一氧化氮（ＮＯ）水平及肌酸磷酸激酶（ＣＰＫ）活性的影响。结果显示：在犬急性心肌缺血过程中血清ＣＰＫ活性和血浆ＥＴ水平均显著增高，血清ＮＯ水平下降。愈心痛胶囊两个剂量组均可明显抑制实验性犬心肌损伤时ＣＰＫ的溢出和血浆ＥＴ的过量释放，同时促进ＮＯ的生成和释放，与盐水对照组比较差异显著（Ｐ＜０．０５～０．００１），从而保护心肌免受缺血性损伤，其作用效果与剂量呈正相关。

英文摘要:

Effect of Yuxintong(YXT) capsule on plasma endothelin(ET), serum nitric oxide(NO) and creatine phosphokinase(CPK) activity in experimental acute myocardial ischemia dogs were observed. The results indicated that in acute myocardial ischemia dogs, the serum CPK activity and plasma ET level increased and serum NO level decreased significantly. In comparing with control,YXT not only could reduce significantly the increased plasma ET content and serum CPK activity,but also increase markedly the producing and releasing of NO, P<0.05～0.001. Therefore, it could protect the myocardia from ischemic damage, the efficacy of YXT was positively dose dependent

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