阿托品对枳实增强犬小肠电活动效应的影响

作者	单位
黄子荷	南京铁道医学院
杨德治	南京铁道医学院
魏义全	南京铁道医学院
应崇智	南京铁道医学院
毕庆和	南京铁道医学院

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中文摘要:

本研究应用电生理结合微机系统处理方法，以消化间期综合肌电为指标，观察并记录了给清醒、健康、空腹犬以１００％枳实浓缩液（１ｍｌ／ｋｇ）灌胃后产生的增强小肠电活动的效应，可被胆碱能受体阻断剂阿托品明显抑制，表现为Ⅱ相和总周期虽有延长，但Ⅱ、Ⅲ相及总周期内平均每簇中快波数均减少，每分钟快波数也减少，提示枳实的作用可能与Ｍ受体有关。

英文摘要:

Effect of Fructus Aurantii Immaturus(FAI) was observed by using the computerized electrophysiologic method with the interdigestive myoelectric complex(IDMEC) as criterion. 100% FAI was given to the healthy, awakened and fasting dogs by gastrogavage and as soon as the effect on electric activity of small intestine appeared, atropine was injected. Results showed that the enhancing effect of FAI could be inhibited significantly by atropine, an antagonist of cholinergic receptor.It revealed that although the duration of phase Ⅱ and general cycle were prolonged, but the spike burst per cluster in the duration between phase Ⅱ and phase Ⅲ as well as that per minute were decreased. It suggested the effect of FAI might be relevant with muscarinic receptor.

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