| 李晓明,施赛珠,牛惠志,石志芸.血浆α－颗粒膜蛋白140测定在原发性肾小球疾病血瘀证中的临床意义[J].中国中西医结合杂志,1996,(6):344-346 |
| 血浆α－颗粒膜蛋白140测定在原发性肾小球疾病血瘀证中的临床意义 |
| Clinical Significance of Plasmaα-Granule Membrane Protein-140 in Blood Stasis of Primary Glomerular Disease |
| 免费下载全文 查看/发表评论 下载PDF阅读器 |
| |
| DOI： |
| 中文关键词: 血浆α－颗粒膜蛋白140 原发性肾小球疾病 血瘀证 气虚 |
| 英文关键词:plasmaα-granule membrane protein-140 primary glomerular disease bloodstasis Qi-Deficiency |
| 基金项目: |
|
| 摘要点击次数: 1319 |
| 全文下载次数: 1050 |
| 中文摘要: |
| 本研究测定５３例血瘀证和非血瘀证原发性肾小球疾病（ＰＧＤ）患者血浆α－颗粒膜蛋白１４０（ＧＭＰ－１４０）浓度，并观察ＰＧＤ患者中高血脂、高血压与ＧＭＰ－１４０的关系。结果显示：ＰＧＤ患者血浆ＧＭＰ－１４０浓度明显高于对照组（Ｐ＜０．０１），血小板处于高度活化状态，其中血瘀证组显著高于非血瘀证组（Ｐ＜０．０１），血瘀证患者中气虚组高于非气虚组（Ｐ＜０．０５），说明ＧＭＰ－１４０是反映ＰＧＤ血瘀证的客观指标，气虚能加重血小板活化，加重血瘀倾向，符合中医“气虚血瘀”理论。高血脂、高血压与ＧＭＰ－１４０异常增高密切相关，是造成ＰＧＤ高凝状态、血瘀倾向的重要因素。 |
| 英文摘要: |
| Plasma a-granule membrane protcin 140(GMP-140) was determined in 53 patients of primary glomerular disease(PGD) with or without blood stasis.At the same time,the relationships between plasma GMP-140 and hyperlipoidemia and hypertension were investigated. Results showed that plasma GMP-140 in PGD patients was higher than that of normal control subjects,P<0.01, platelet of patients was in a high activated status.The elevation was more significant in patient with blood stasis than in those without blood stasis,P<0.01.Among the patients with blood stasis,plasma GMP-140 level in those with Qi-Deficiency was higher than that without Qi-Deficiency(P<0.05)The above-mentioned results suggested that GMP- 140 was an objective indicator for blood stasis of PGD patients.Deficiency of Qi could enhance platelet activation so as to aggravate the tendency of blood stasis.It was in accordance with the traditional Chinese medicine theory of "Qi-Deficiency induces blood stasis".Hyperlipoidemia and hypertension showed close relationship with abnormalincrease of GMP-140,suggesting they play important roles in induction of hypercoagulability and blood stasis in PGD patients. |
| 关闭 |
扫描微信二维码，获取更多信息