| 桑雁,王宪波,韩清,郭宝瑞,刘喜新.糖肾康胶囊治疗糖尿病肾病的临床观察[J].中国中西医结合杂志,1996,(7):398-401 |
| 糖肾康胶囊治疗糖尿病肾病的临床观察 |
| Effects of Tangshenkang Capsule on Diabetic Nephropathy |
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| DOI： |
| 中文关键词: 糖肾康胶囊 糖尿病肾病 血栓素B2 6－酮－前列腺素F1α 过氧化脂质 |
| 英文关键词:Tangshenkang capsule diabetic nephropathy thromboxane B2 6-keto-PGF1α lipid peroxidase |
| 基金项目:河南省中医管理局资助 |
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| 中文摘要: |
| 将５７例糖尿病肾病（ＤＮ，其中早期４８例，临床期９例），随机分成两组，观察比较了糖肾康胶囊加西药常规治疗和常规治疗对ＤＮ患者的影响。结果显示：糖肾康胶囊组治疗６周后，患者尿白蛋白平均下降８１．６０ｍｇ／ｄ（５１．０％，Ｐ＜０．０１），且尿白蛋白排泄量与血浆血栓素Ｂ２（ＴＸＢ２）／６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）比值呈正相关，有效肾血浆流量增加（Ｐ＜０．０１），肾小球滤过分数下降（Ｐ＜０．０５），肌酐清除率无明显变化，血浆过氧化脂质水平降低（Ｐ＜０．０１）；常规治疗组治疗６周后，病情无明显改善。这表明糖肾康胶囊对ＤＮ患者具有降低尿白蛋白排泄和改善肾功能作用，这可能与其改善ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α平衡和抗脂质过氧化等作用有关。 |
| 英文摘要: |
| To study the effects of Chinese herbal medicine Tangshenkang(TSK) capsule on diabetic nephropathy(DN),57 patients with DN were randomly divided into two groups,the treated group and the control group,they were treated with TSK capsule and the conventional therapy respectively.There were serious disorders of metabolism in DN patients,that showed the TXB 2/6keto-PGF1α ratios and lipid peroxidase(LPO) levels were higher than that of healthy people.After 6 weeks treated with TSK capsule the albuminuria levels reduced obviously(decreased 51%),renal plasma flow(RPF) increased,glomerular filtration rate and the LPO levels decreased and a positive correlation was observed between albuminuria levels and TXB 2/6-keto-PGF 1α ratios while the clearance rate of creafinin didn’t improve significantly.There were no significant difference in the above-mentioned parameters in the control group before and after treatment.These results suggested that TSK capsule possessed a significant effect in improving albuminuriaand glomerular function. And the effect of TSK might be due to its adjusting TXB 1/6-keto-PGF 1α ratios and its lipid-peroxidation in DN patients. |
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