脉络通冲剂抗血栓闭塞性脉管炎的实验研究

作者	单位
王军	河南省中医药研究院
王玉升	河南省中医药研究院
付蔓华	河南省中医药研究院
陈国华	河南省中医药研究院

摘要点击次数: 1278

全文下载次数: 1058

中文摘要:

本实验用月桂酸溶液注射于大鼠股动脉，造成血栓闭塞性脉管炎动物模型，观察脉络通冲剂的治疗作用。结果表明：该品能明显减轻模型大鼠患肢病变程度和范围；显著降低血浆粘度和纤维蛋白原含量；抑制动脉血栓形成、内皮细胞增生及中膜和外膜的炎性细胞浸润。提示脉络通冲剂可通过改善血液流变性、抗血栓形成及溶血栓、减轻血管内皮细胞增生和血管壁炎症反应等多种途径实现对血栓闭塞性脉管炎的治疗作用。

英文摘要:

Using experimental model of thromboangitis obliterans(TAO) in rats induced by injection of lauric acid into the femoral artery,the anti-thromboangitis obliterans effects of Mailuotong(MLT) Granule were observed.The results showed that MLT not only decreased significantly the lesion severity and extent of affected limb,plasma viscosity and level of fibrinogen,but also suppressed the arterial thrombosis,endotheliocytosis and inflammatory cell infiltration in vascular wall.MLT also reduced the organization of thrombus and facilitated thrombolysis.It showed that the therapeutic effect of MLT on TAO might be achieved by improving blood rheology,antithrombosis,thrombolysis,inhibiting endotheliocytosis and inflammatory reaction in vascular wall.

关闭