温肠宁口服液治疗婴幼儿秋季腹泻的临床与实验研究

本研究对温肠宁口服液治疗婴幼儿秋季腹泻寒湿证进行临床疗效观察，治疗组２３８例，痊愈率８１．９％，显效率８９．１％，总有效率９２．９％，并与对照组（霍香正气水组３２例与庆大霉素组５Ｏ例）疗效对比，无论在痊愈率、显效率、总有效率、止泻时间及临床症状消失时间方面，均有显著性差异（Ｐ＜０．０１，Ｐ＜０．００１））。临床及动物实验证实该药无毒副作用。其治疗机理可能为：（１）抗轮状病毒，抗腹泻；（２）促进肠道消化、吸收功能的恢复；（３）提高机体免疫功能；（４）抑制肠管运动。此药见效快、服用安全、方便，符合世界卫生组织对防治腹泻新药的要求。

英文摘要:

Cold-Dampness Syndrome of Infantile Autumn diarrhea treated with Wenchangning Oral Liquor was observed clinically. There were 238 cases in the treated group, the cure rate was 81.9%.In comparing with control group (32 cases in Huoxiang Zhengqi Liquid group, 50 cases in gentamycin group), there were highly significant difference between treated and control groups in the cure rate, markedly effective rate, total effective rate, time for stopping diarrhea and for disappearing of clinical symptoms, P <0.01 and <0.001. Clinical practice and animal experiments revealed that the drug had no toxic and side-effects. The possible therapeutic mechanisms were:(1)Anti-Rotavirus, anti-diarrhea, (2) Promote the recovery of intestinal digestive and absorptive function, (3) Enhance the immune function of the body, (4) Inhibit the motility of intestinal tract,Wenchangning Oral Liquor is rapid in action, conveniant in administration and safe, conforming to the criteria for the preventing and treating diarrhea of World Health Organization.

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