丹参防治实验性动脉再狭窄及其机制的初步研究

作者	单位
周小明	同济医科大学附属同济医院心内科
陆再英	同济医科大学附属同济医院心内科
汪道文	同济医科大学附属同济医院心内科

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中文摘要:

动脉再狭窄严重影响了经皮腔内冠状动脉成形术（ＰＴＣＡ）的远期疗效。为评价丹参用于防治再狭窄的可能性，本研究利用大鼠动脉再狭窄模型，观察了丹参对动脉去内皮后内膜增生的影响，并观察了丹参注射液对离体培养的兔动脉平滑肌细胞（ＳＭＣ）增殖的影响。结果表明，丹参注射液在体外抑制培养的ＳＭＣ增殖，在体内抑制动脉去内皮后的内膜增生，提示丹参有望成为防治再狭窄的有效药物。

英文摘要:

Eor evaluating the possibility of Salvia miltiorrhiza(SM) on the prevention of arterial restenosis after angioplasty, we investigated the effect of SM on the intimal thickening of air-injured carotid artery of rats. The results showed that the maximal intimal thickness of the injured arteries was much thinner in the treatment group than that in the control group, indicated that SM could prevent experimental restenosis in rat model. Furthermore, we examined the effect of SM on the proliferation of the isolated rabbit artdrial smooth muscle cells (SMC) cultivated in vitro. The results showed that SM inhibited the ￣3H-TdR take-up and proliferation of SMC in a dose-dependent manner. The study raised the possibility that SM could be used to prevent arterial restenosis after angioplasty.

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