尿毒净治疗慢性肾功能衰竭的临床研究

作者	单位
王永钧	杭州市中医医院
徐琳	杭州市中医医院
程晓霞	杭州市中医医院
朱彩凤	杭州市中医医院
李慧	杭州市中医医院
俞东蓉	杭州市中医医院
郑文龙	杭州市中医医院

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中文摘要:

将１０５例慢性肾功能衰竭（ＣＲＦ）患者分为中药尿毒净治疗组（７５例）和包醛氧化淀粉对照组（３０例），并进行自身治疗前后对照和组间对照观察。结果：治疗组对ＣＲＦ的总有效率和显效率（分别为７４．７％与４４．０％）优于对照组（５６．７％和２３．３％，Ｐ＜０．０５）。治疗组治疗后血清肌酐（Ｓｃｒ），血尿素氮（ＢＵＮ），血浆中分子物质（ＭＭＳ）比治疗前均有显著下降（Ｐ＜０．０５～０．０１），内生肌酐消除率（Ｃｃｒ）比治疗前有显著升高（Ｐ＜０．０５）；且Ｓｃｒ，ＭＭＳ降低及Ｃｃｒ升高幅度高于对照组（Ｐ＜０．０５～０．０１）。尤对氮质血症及早期尿毒症疗效较好。

英文摘要:

One hundred and five chronic renal failure patients were divided randomly into two groups, 75 cases of Niaodujing(NDJ) treatment group and 30 cases of control group treated with aldehyde coated oxystarch.The effects were compared between two groups and within the same group before and after the entry.Results indicated that the total effective rate and markely effecive rate of NDJ group(74. 1% and 44.0%) were better than those of the control group(56.6% and 23.3%) respectively(P<0.05).The serum creatinine, blood urea nitrogen and middle molecular substance were decreased and creatinine clearance rate was increased significantly after NDJ treatment as compared with before treatment(p<0.05～0.01).In comparison of two groups, the decrement of creatinine clearance rate and middle molecular substance and the increment of creatinine in NDJ group were higher than that in control group(P<0.05～0.01). NDJ was especially effective in patients with azotemia or early renal failure.

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