复方丹参注射液对Ⅱ型糖尿病患者抗脂质过氧化损伤的影响

Effect of Salvia Miltiorrhiza Composita on Superoxide Dismutase and Malonyldialdehyde in Treating Patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM)

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DOI：

中文关键词: Ⅱ型糖尿病复方丹参注射液超氧化物歧化酶丙二醛

英文关键词:non-insulin dependent diabetes mellitus Salvia Miltiorrhiza Composita superoxide dismutase malonyldialdehyde

基金项目:

作者	单位
姜兆顺	济南军区总医院
张胜兰	济南军区总医院
蔡新吉	济南军区总医院
邢万佳	济南军区总医院
王素霞	济南军区总医院

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中文摘要:

目的：为探讨复方丹参注射液对Ⅱ型糖尿病患者的临床治疗意义。方法：观察加用与未用复方丹参注射液治疗的Ⅱ型糖尿病患者各２０例，治疗前后患者血清超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量的变化，并分别与２０名健康人作比较。结果：Ⅱ型糖尿病患者ＳＯＤ明显低于健康人（Ｐ＜０．０５），ＭＤＡ明显高于健康人（Ｐ＜０．０１）。加用复方丹参注射液治疗后，患者ＳＯＤ明显升高（Ｐ＜０．０５），ＭＤＡ明显下降（Ｐ＜０．０１），均接近于正常；未用复方丹参注射液者虽有ＳＯＤ升高与ＭＤＡ下降，但与健康人比较仍有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。前者抗脂质过氧化损伤总有效率为９０％，明显高于后者的总有效率６０％（Ｐ＜０．０１）。结论：Ⅱ型糖尿病患者存在脂质过氧化损伤，复方丹参注射液能有效对抗这种损伤，因而对控制糖尿病并发症具有重要意义。

英文摘要:

To assess the effect of Salvia Miltiorrhiza Composita (SMCo) in treating non-insulin-de-pendent diabetes melitus (NIDDM). Methods: The superoxide dismutase (SOD) and malonyldialdehyde (MDA) levels of 20 patients with NIDDM were observed before and after treatment with Salvia Miltiorrhiza Composita and 20 patients without using SMCo were studied as controls. Results: The SOD levels were significantly lower than that of normal (P <0. 05), and MDA significantly increased (P <0.01). After treatment with SMCo, the SOD levels were significantly’ increased (P < 0. 01), there was no difference between the treatment group and the normal group. In the control group, the SOD levels had increase tendency and MDA had decrease tendency, but there was significant difference compared with the normal (P <0.05, P <0.01 respectively). The total effective rate of anti-lipid peroxidation injury in the group combined with intravenous SMCo was markedly higher than in the group without SMCo therapy (90% vs 60%, P < 0. 01). Conclusion: SMCo could resist lipid peroxidation injury.

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