四君子汤对脾虚大鼠胃动素及川芎嗪药物动力学特征的影响

目的：探索胃肠动力学与药物动力学（ＰＫ）的关系。方法：同步观察脾虚证大鼠血浆和肠组织中胃动素（ＭＯＴ）的含量及其磷酸川芎嗪（ＴＭＰＰ）的ＰＫ特征，并用四君子汤反证，探讨“证”、“辨证施治”与ＰＫ间的关系。结果：ＴＭＰＰ在脾虚证、正常和四君子汤治疗大鼠的房室模型均为开放型二室模型；正常和四君于汤治疗大鼠间的ＭＯＴ含量、ＴＭＰＰ的ＰＫ参数及血药浓度等观察指标无明显差异；模型和正常组间上述指标差异显著（Ｐ＜０．０１）．结论：大鼠的脾虚状态明显地影响ＴＭＰＰ在体内的吸收、分布、代谢和排泄；四君子汤可恢复脾虚大鼠异常的ＴＭＰＰ的ＰＫ特性；为验证“辨证药动学”假说提供了进一步的科学依据。

英文摘要:

To explore relationship between the essence of Spleen Deficiency Syndrome (SDS) and pharmacokinetic characteristics (PK). Mehtods: The level of motilin in serum and intestine, and PK of tetramethylpyrazine Phosphate (TMPP) in rat model of SDS were observed simultaneously and treated with Sijtinzi decoction (SJZD)for confirmation. Results:The atrioventricular model of TMPP in SDS, normal and SJZD treated rats all belonged to the open double ventricular type; there were insignificant differences between normal and SJZD treated rats in motilin level and PK of TMPP, but the differences of these parameters between normal and SDS model rats were significantly (p<0.01). The SDS state could markedly affect the absorption, distribution, metabolism and elimination of TMPP in rat; SJZD could normalize the abnormal PK of TMPP in SDS model rats. Conclusion: A supplementary scientific evidence for the hypothesis of pharmacokinetics of Syndrome Differentiation is provided.

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