中西医结合治疗肝豆状核变性临床研究

作者	单位
任明山	安徽中医学院附属医院神经病学研究所
张波	安徽中医学院附属医院神经病学研究所
杨任民	安徽中医学院附属医院神经病学研究所
韩咏竹	安徽中医学院附属医院神经病学研究所
王训	安徽中医学院附属医院神经病学研究所

摘要点击次数: 1383

全文下载次数: 1076

中文摘要:

目的：观察中西医结合治疗肝豆状核变性（ＨＬＤ）的疗效。方法：８０例ＨＬＤ患者被随机分为中西组和对照组，对照组以二巯基丁二酸（ＤＭＳＡ）治疗。每日５０ｍｇ／ｋｇ，分两次口服。中西组在ＤＭＳＡ治疗的基础上加服中药肝豆汤，每日２次。两组疗程均为１个月，疗程前后分别进行病情分型、分级和疗效判定，并检测患者２４ｈ尿铜、锌、铁及钙含量。结果：（１）中西组的总有效率及其中肝型患者的有效率显著优于对照组（Ｐ＜０．０５）。（２）两组经１个月治疗后，２４ｈ尿微量及宏量元素均较疗前显著增高（Ｐ＜０．０１）。（３）中西组副反应发生率（１７．５％）虽低于对照组（２２．５％），但无统计学意义。结论：中西医结合治疗适合临床应用，尤其对目前治疗比较棘手、疗效较差的肝型患者更值得推荐。

英文摘要:

To investigate the curative effect of integrated traditional and western medicine (TCM-WM) therapy on hepatolenticular degeneration (HLD ). Methods: Eighty patients with HLD were divided randomly into two groups (TCM-WM group and WM group ) .TCM-WM group(40 cases)were given orally dimercaptosuccinic acid (DMSA )and Gandou (肝豆)decoction for 1 month. The efficacy was compared with that of 40 cases treated with DMSA as the control. The changes of urinary trace and macro-elements before and after treatment were observed. Results: The total effective rate of TCM-WM group was significantly higher than that of WM group (P<0. 05), especially more patients with hepatic type responded well to treatment with TCM-WM than with only chelating agent DMSA. Urinary trace and macro-elements were all obviously elevated in patients of two groups after treatment (P<0. 01). Conclusion: TCM-WM therapy appears extremely promising as new cupruretic method for treatment of HLD. It is particularly suitable for treating the patient with hepatic type.

关闭