青蒿琥酯片不同疗程治疗恶性疟疾疗效比较

作者	单位
李广谦	广州中医药大学热带医学研究所
符永新	广州中医药大学热带医学研究所
卞维秀	广州中医药大学热带医学研究所
郭兴伯	广州中医药大学热带医学研究所

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中文摘要:

目的：观察青蒿琥酯片不同疗程治疗恶性疟疾的疗效。方法：采用青蒿琥酯片３天、５天和７天疗程总量４００ｍｇ、６００ｍｇ和８００ｍｇ，治疗恶性疟疾９０例。结果：全部临床治愈。各组间平均退热时间、原虫转阴时间相似。２８天原虫复燃率３天疗程组为３９．３％（１１／２８例）、５天疗程组为６．９％（２／２９例）和７天疗程组为３．４％（１／２９例），５天疗程组与３天疗程组比较，Ｘ２＝８．４８９，Ｐ＜０．００５；７天组与３天组比较，Ｘ２＝１１．００８，Ｐ＜０．００５；７天组与５天组比较，Ｘ２＝０。结论；延长青蒿琥酯片疗程可以有效地降低２８天原虫复燃率。

英文摘要:

To assess the efficacy of Artesunate on falciparum malaria. Methods: A randomized controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out with 400 mg of artesunate tablet as a total dose over 3 days, 600 mg over 5 days and 800 mg over 7 days. Results: All patients were cured. Fever clearance time (FCT)and parasite clearance time (PCT ) among the three groups were similar. Parasite recrudescence rate within 28 days was 39. 3% (11/28)in 3 day group, 6. 9% (2/29)in 5 day group and 3. 4 % (1/29) in 7 day group(comparing 5 day group with 3 day group,P<0. 005,comparing 7 day group with 3 day group, P<0. 005). Conclusion: It indicated that parasite recrudescence rate may be effectively decreased by prolonging treatment courses.

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