血府逐瘀丸对患者颈动脉粥样硬化的影响

目的：观察血府逐瘀丸对患者颈动脉粥样硬化的影响。方法：采用彩色多普勒颈动脉超声法，对中药复方血府逐瘀丸治疗１０例颈动脉粥样硬化患者的疗效进行了观察。结果：血府逐瘀丸治疗的患者，其颈总动脉内膜－中膜厚度有所降低，治疗前后差值为０．１３±０．０３ｍｍ（Ｐ＜０．００１），对颈动脉粥样硬化斑块的厚度和面积分别降低０．１１±０．０５ｃｍ和０．０９±０．０４ｃｍ２（Ｐ均＜０．０５）；而阿斯匹林治疗的对照组患者其颈总动脉内膜－中膜厚度、动脉粥样硬化斑块的厚度和面积均无明显变化（Ｐ均＞０．０５）。结论：血府逐瘀丸对颈动脉粥样硬化病变有一定的治疗作用。

英文摘要:

To observe the effect of Xuefuzhuyu Pill(XFZYP) on carotid atherosclerosis. Methods:The patients were randomly divided into XFZYP group and aspirin control group. The status of the carotid plaque vessel wall and bind flow were observed by colored Doppler ultrasonography. Results: (1 )Plaque of 6 cases regressed, of 6 cases unchanged, of 1 case progressed after treatment of XFZYP. The area of plaques between baseline and after treatment decreased 0. 11 ± 0. 05cm and that of thickness reduced for 0. 09± 0. 04cm2 (P<0. 05)in XFZYP group. While plaque of 3 cases regressed,of 6 unchanged,of 2 cases progressed after treatment of aspirin. The area and thickness of plaque were reduced to 0. 05± 0. 04cm and 0. 04 ± 0. 03cm respectively. There were no statistic difference in aspirin group. (2)The intima-media thickness of common carotid artery decreased 0. 13±0. 03mm in XFZYP group (P<0. 001 versus baseline),but there were no significant change after treatment of aspirin (P>0. 05). (3)There were no distinct change about peak systole , minimal diastole time average peak,pulsative index,resistive index in common carotid artery and internal carotid artery after treatment of XFZYP and aspirin. Conclusion: Colour Doppler ultrasonography of carotid artery provide a noninvasive,safe and valid opportunities for clinical trail. XFZYP can be useful for the treatment of carotid atherosclerosis.

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