补肾生精汤对肾阳虚睾丸功能损害大鼠模型作用的实验研究

作者	单位
岳广平	安徽中医学院针灸经络研究所
陈琼	安徽中医学院针灸经络研究所
戴宁	安徽中医学院针灸经络研究所

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中文摘要:

目的：探讨补肾生精汤治疗男性不育症的作用机理。方法：选用２５０ｇ左右的Ｗｉｓｔａｒ系雄性大鼠，每日灌喂腺嘌吟３０ｍｇ／１００ｇ体重，连续３０天，大鼠出现与人类肾阳虚相似的症状，生育力低下，睾丸生精功能障碍，血中促黄体生成激素（ＬＨ）、睾酮（Ｔ）和皮质醇（Ｆ）含量均比正常组大鼠显著降低（Ｐ＜０．０１）。造模后，中药治疗组大鼠每日饮服补肾生精汤药液３ｍｌ／１００９体重（每毫升药液含生药２ｇ），连续服药１０天，间歇３天再服，共服药３０天。结果：中药治疗组大鼠肾阳虚症状明显改善，生育力、精子质量和睾丸生精功能均显著提高，血中ＬＨ、Ｔ、Ｆ水平显著升高，与非治疗模型组相比，差别均有显著性意义（Ｐ＜０．０５）。结论：补肾生精汤具有壮阳生精和调节内分泌功能的作用。

英文摘要:

Objective: To explore the therapeutical mechanism of Bushen Shengjing Decoction (BSSJD) in treating infertility. Methods: Fed Wistar male rats with adenine 30mg/100g.d continuously for 30 days. The rats manifested the symptom which was similar to the human Kidney Yang Deficiency, the genitality dropped, the function of sperm-producing in the testis was disturbed, the contents of luteinizing hormone (LH), testosterone (T) and compound F (F) in blood were all lower than rats of normal group, P<0. 01. The model rats took the BSSJD 3 ml/100g .d (each ml contains crude drugs 2g)continuously for 10 dsys,interval for three days, then medicated again and total medication of BSSJD was 30 days. Resulta: The symptom of Kidney Yang Deficiency in rats was improved obviously, the genitality, sperm quality and function of sperm producing in testis were all enhanced obviously, so did the hormone level of LH, T, F in blood. Comparing to untreated control group, the difference was significant (P<0. 05). Conclusion: BSSJD has the function of reinforcing Yang and replenishing essence and regulate the endocrinological function.

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