益气养阴中药为主治疗Graves病的疗效及其机理探讨

Therapeutic Effect and Its Mechanism Exploration on Mainly Using Traditional Chinese Medicine of Replenishing Qi and Nourishing Yin in Treating Graves Disease

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DOI：

中文关键词: Graves病益气养阴钠泵活性

英文关键词:Graves disease replenishing Qi and nourishing Yin activity of sodium pump

基金项目:

作者	单位
查良伦	上海医科大学中西医结合研究所

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中文摘要:

目的：探讨益气养阴中药为主加小剂量他巴唑联合用药对Ｇｒａｖｅｓ病的疗效及机理研究。方法：将８４例Ｇｒａｖｅｓ病患者分为联合用药（治疗组４２例）及单用西药（对照组４２例）观察比较治疗前后甲状腺功能及红细胞钠泵活性变化。结果：两组治疗０．５年、１年和２年后血清Ｔ３、Ｔ４浓度均明显低于治疗前，但治疗组疗效显著优于对照组；Ｇｒａｖｅｓ病患者的红细胞钠泵活性明显高于健康人组，治疗１年和２年后，患者的红细胞钠泵活性明显低于健康人组及治疗前，与对照组比较，有显著性差异（Ｐ＜０．００１）。结论：益气养阴中药为主加小剂量他巴唑联合治疗具有改善Ｇｒａｖｅｓ病患者的甲状腺功能和能量代谢的作用，且优于单用西药组。

英文摘要:

To explore the therapeutic effect and its mechanism mainly using traditional Chinese medicine (TCM) of replenishing Qi and nourishing Yin (RQNY) with a small dosage of Tapazol for treatment of Graves disease (GD). Methods: The changes of thyroid function and the activity of sodium pump of human erythrocyte in the patients with Graves disease were observed and compared before and after treatment between the treated group (42 cases) by combining treatment mainly using TCM of RQNY and a small amount of Tapazol, and a control group (42 cases) by Tapazol alone.Results: After treatment for half a year, one and two years, the serum levels of T3, T4 in above two groups were markedly decreased than those of before treatment, the therapeutical effect of treated group was superior to that of control group. The activity of sodium pump in human erythrocyte in the GD patients was obviously higher than that of normal group and that of before treatment. After treatment for one and two years mainly by TCM or Western medicine, the erythrocyte sodium pump activity was obviously lower than that of before treatment and that of normal group. The decrease of erythrocyte sodium pump activity in group of combination therapy was markedly lower than that in group of Western medicine. Conclusion: Combination therapy was much more effective on the functional remission of thyroid and energy metabolism in GD patients than that of using Tapazol therapy only.

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