复方丹参对冠心病患者红细胞膜磷脂成分的影响

目的：探讨磷脂代谢在冠心病发病中的作用以及复方丹参对其影响。方法：采用薄层色谱扫描法和荧光法测定冠心病（Ｃｏｒｏｎａｒｙｈｅａｒｔｄｉｓｅａｓｅ，ＣＨＤ）患者红细胞膜磷脂各成分以及过氧化脂质（Ｌｉｎｉｄｐｒｅｒｏｘｉｄｅ，ＬＰＯ）、超氧化物歧化酶（Ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，ＳＯＤ）和谷胱甘肽过氧化物酶（Ｇｌｕｔａｔｈｉｏｎｅｐｅｒｏｘｉｄａｓｅ，ＧＳＨ－Ｐｘ）含量及复方丹参治疗后上述各项指标的改变。结果：冠心病患者红细胞膜磷脂成分中的神经磷脂（Ｓｐｈｉｎｇｏｍｓｅｉｎｓ，ＳＭ）、磷脂酰丝氨酸（Ｐｈｏｓｐｈａｔｉｄｙｌｓｅｒｉｎｅ，ＰＳ）、磷脂酰乙醇胺（Ｐｈｏｓｐｈａｔｉｄｙｌｅｔｈａｎｏｌａｍｉｎｅ，ＰＥ）和溶血磷脂（Ｌｙｓｏｐｈｏｓｐｈａｔｉｄｅ，ＬＬ）增高，磷脂酰胆碱（Ｐｈｏｓｐｈａｔｉｄｙｌｃｈｉｏｌｉｎｅｓ，ＰＣ）较对照组降低，其中ＳＭ／ＰＣ和ＰＳ／ＰＣ比值明显增高。冠心病患者ＬＰＯ明显增加，ＳＯＤ／ＬＰＯ和ＧＳＨ－ＰＸ／ＬＰＯ明显降低。复方丹参治疗后ＳＭ／ＰＣ和ＰＳ／ＰＣ比值以及ＬＰＯ明显降低，ＰＣ和ＳＯＤ／ＬＰＯ明显增高。结论：红细胞膜磷脂成分异常参与冠心病的发生和发展，丹参可改善

英文摘要:

To investigate the function of phospholipid metabolism in pathogenesis of coronary heart disease (CHD) and the effect of Salvia miltiorrhizae Composita (SMC) on it. Methods: The levels of erythrocyte membrane phospholipid, blood lipid peroxide (LPO ), superoxide dismutase (SOD)and glutathione peroxidase (GSH-Px) were determined in the patients with CHD by Thinlayer chromatography and fluorimetry during the treatment of SMC. Results: Sphingomyelins(SM),phosphatidyl serine (PS ), phosphatidyl ethanolamine (PE ) and lysophosphatide (LL ) of erythrocyte membrane phospholipid were increased in patients with CHD. Phosphatidyl cholines (PC)was lower than control group. Among them,the ratios of SM/PC and PS/PC were significantly higher. In the patients with CHD, LPO was significantly increased and ratios of SOD/LPO and GSH-Px/LPO significantly decreased. After the treatment with SMC, LL, SM, PS and PE of erythrocyte phospholipid and the ratios of SM/PC and PS/PC and LPO were decreased. PC and SOD/LPO were increased. Conclusions: The abnormality of erythrocyte membrane phospholipid participate the occurrence and development of CHD. SMC might improve the abnormality of erythrocyte phospholipid and lipid peroxide and possess the effect of regulating phospholipid metabolism.

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