免疫异常增高型反复自然流产的中西医结合治疗

作者	单位
李大金	上海医科大学妇产科研究所生殖免疫室
李超荆	上海医科大学妇产科研究所生殖免疫室
朱影	上海医科大学妇产科研究所生殖免疫室
王文君	上海医科大学妇产科研究所生殖免疫室
王明雁	上海医科大学妇产科研究所生殖免疫室
孙晓溪	上海医科大学妇产科研究所生殖免疫室
孟毅	上海医科大学妇产科研究所生殖免疫室
邵彦红	上海医科大学妇产科研究所生殖免疫室

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中文摘要:

目的：探讨以中药为主的中西医结合疗法治疗免疫异常增高型反复自然流产的临床价值及其作用机理。方法：免疫异常增高型反复自然流产透明带抗体阳性者采用知柏地黄丸治疗；磷脂抗体及ＡＢＯ血型机体阳性者采用清热利湿、养血活血中药复方治疗，磷脂抗体阳性者加用阿司匹林口服。结果：经治疗后，再次妊娠成功率为９２．３％。在治疗过程中，透明带抗体、磷脂抗体及ＡＢＯ血型抗体水平呈明显下降。妊娠后透明带抗体水平无明显再次升高现象；而磷脂抗体及ＡＢＯ血型抗体水平于妊娠后再度升高，但经继续治疗后又呈明显下降。结论：中药复方主要通过降低异常增高的自身及同种抗体水平，可有效治疗免疫异常增高型反复自然流产。

英文摘要:

Objective:Immune abnormality type of recurrent spontaneous abortion (RSA) is an important etiological type, major findings Of that are the abnormal increases in auto and/or allo-antibodies of anti-zona pellucida,antiphospholipid and anti-ABO blood group. In the present study, to assess the clinical values of integrated traditional and Western medicine and its therapeutic mechanisms in treating immune abnormality type of RSA. Methods:Aborters were treated by Zhibai Dihuang Pills for anti- zona pellucida antibodies, and dear evil Heat, remove Dampness, replenish blood and activate circulation by Chinese medicinal herbs recipe for anti-phospholipid and anti ABO group antibodies. Results: After they had been treated by these recipe, 92. 3% of them became pregnant with normal delivery. It was found in dynamic investigation that level of the antibodies turned to decrease gradually during the treatment, and that of anti-phospholipid and anti-ABO group antibodies increased again at beginning of pregnancy and then decreased gradually with continuing pregnancy. Conclusion: Chinese herbs recipe could be used to treat RSA of the immune abnormality type by way of decreasing the elevated levels of auto and/or allo-antibo dies.

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