益智胶囊治疗老年血管性痴呆临床研究

作者	单位
陈楷	中国中医研究院老年医学研究所
陈可冀	中国中医研究院老年医学研究所
周文泉	中国中医研究院老年医学研究所
崔玲	中国中医研究院老年医学研究所
涂人顺	中国中医研究院老年医学研究所
高普	中国中医研究院老年医学研究所
李浩	中国中医研究院老年医学研究所
张昱	中国中医研究院老年医学研究所
刘丽	中国中医研究院老年医学研究所

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中文摘要:

目的：观察益智胶囊治疗老年血管性痴呆（Ｖａｓｃｕｌａｒｄｅｍｅｎｔｉａ，ＶａＤ）的临床疗效。方法：６１例ＶａＤ患者随机分为治疗组与对照组。其中治疗组３２例，采用益智胶囊治疗，每次４粒，每日３次口服。对照组２９例，给予喜得镇，每次２ｍｇ，每日３次口服。均２个月为１个疗程，单育给药。结果：本药可以显著增高不同痴呆量表成绩；显著改善中医临床症状、神经功能缺损和生活能力，改善平衡能力，对脑动脉血流速度异常降低有一定改善作用，对脑电地形图有一定改善作用；对异常血粘度患者可以降低其不同切变率下全血粘度，且降低血浆粘度，对红细胞变形和聚集指数异常者均有显著改善作用。结论：提示益智胶囊对老年血管性痴呆确有一定治疗作用。

英文摘要:

Objective:To assess the efficacy of Yizhi capsule (YZC) in treating senile dementia.Methods:Sixty-one vascular dementia (VaD) patients were randomly divided into YZC and control groups. There were 32 cases in YZC group, 4 capsules each time three times a day.In control group, there were 29 cases, 2 mg of hydergine were given each time three times a day, single-blind method was used and the treatment course was two months. Results:YZC could remarkably increase mini-mental state examination (MMSE) and Hamilton Depression Scale (HDS) marks of VaD patients. YZC had the effect of improving balance and gait ability of VaD patients. YZC could improve the abnormal blood velocity (By), as well as improve cerebral blood now, brain electrical activitymonitoring (BEAM) and hemorheological indexes especially for the abnormal case. No side-effect or toxic-effect was observed in the administration period. Conclusion: YZC had certain effect on senile VaD, and it was safe in application.

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