脂肝乐胶囊治疗痰湿瘀阻型脂肪肝的临床与实验研究

为探讨脂肝乐胶囊治疗痰湿瘀阻型脂肪肝疗效机理。方法：运用脂肝乐胶囊治疗痰湿瘀阻型脂肪肝患者１４６例（治疗组），并与用东宝肝素片治疗的４７例（对照组）作对照，实验研究观察两药对乙硫氨酸所致脂肪肝模型及大鼠高脂血症模型的影响。结果：治疗组在减轻或去除症状、改变Ｂ超回声，降脂，降酶，改善血液流变性等方面明显优于对照组（Ｐ＜０．０５～０．０１）。动物实验显示：该药可降低血脂，抑制脂肪在肝脏沉积，３个用药组在降低甘油三酯方面与模型组比较有显著性差异（Ｐ＜０．０１）。结论：脂肝乐胶囊具有明显降低甘油三酯，抑制脂肪在肝脏沉积，改善血液流变性的作用。

英文摘要:

To explore the mechanism of Zhiganle capsule (ZGLC) in treating fatty liver of Phlegm-DampnessStagnation type. Methods: One hundred and forty-six patients were treated with ZGLC, the effects were observedand compared with those treated with Dongbao Gantai(DBGT, 东宝肝泰) tablets as control. The effect of ZGLC onethionine induced hyperlipemia model rats was also Observed. Results: The effect of ZGLC was obviously better thanthose of DBGT in relieving or removing symptoms, normalizing the ultrasonic abnormal findings, lowering theserum levels of lipid and enzyme and improving hemorrheologic properties. Experimental study showed that ZGLCcould reduce the blood lipids, inhibit the lipid deposition in liver. As compared with the model group, level oftriglyceride in the ZGLC treatment group were much lowered (P < 0. 01 ) and the effect was better than those inthe control group. Conclusions: ZGLC has the effect of reducing blood triglyceride level, inhibiting lipid depositionin liver and improving hemorrheologic properties.

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