大黄治疗淤胆型婴儿肝炎综合征利胆疗效观察

为观察大黄利胆退黄效应，寻找治疗淤胆型婴儿肝炎综合征最佳给药途径。方法：将６４例患儿分为两组，治疗组４４例口服或（和）经十二指肠内灌注大黄浸泡液，对照组２０例仅给予一般护肝治疗，观察治疗前后血清总胆红素值、丙氨酸转氨酶、谷氨酸转肽酶、十二指肠液胆红素值和肝脏大小变化。结果：治疗组显效１８例，有效２１例，无效３例，恶化２例；而对照组疗效分别为０例，４例，１３例，３例。各项检测指标的改善治疗组优于对照组。结论：大黄具有明显的利胆退黄效果，能促进肝功能恢复，疏通胆小管和微细胆管内胆汁淤积，促进胆汁排泄。

英文摘要:

To evaluate the role of Rhubarb in treating infantile cholestatic hepatitis syndrome (IHS). Methods:Forty-four patients of the treatment group were treated with Rhubarb per os and /or duodenal infusion, 20 cases ofthe control group were treated with general liver protecting therapy such as inosine, vitamin C and glucose. Serumbilirubin, alanine transaminase (ALT) and γ-glutamyl transferase (γ-GT) level, bilirubin in duodenal juice and liver size were observed before and after treatment. Results: In the treatment group, 18 cases were markedly effective, 21 effective, 3 ineffective and 2 were deteriorated, while in the control group, the respective number were 0,4, 13 and 3. Conclusions: Rhubarb was a markedly effective in cholagoging and abating of jaundice, it could promote the recovery of liver function, dredge the cholestasis in cholangiole and micro-cholangiole so as to promote thebile secretion.

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