衍化四君子汤治疗胃粘膜肠化的临床研究

作者	单位
钟伟润	广东省湛江中心人民医院
黄元熹	广东省湛江中心人民医院
崔嘉培	广东省湛江中心人民医院
黄经光	广东省湛江中心人民医院
张浩	广东省湛江中心人民医院
高翔	广东省湛江中心人民医院

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中文摘要:

探索衍化四君子汤对胃癌前病变的治疗效果。方法：以衍化四君子汤治疗经胃镜、病理检查确诊为伴有胃粘膜肠上皮化生（简称肠化）的慢性胃炎患者１１７例，并与用维酶素治疗的８５例作对照观察。经３个月治疗后复查胃镜和病理。结果：对肠化的治愈率和总有效率，治疗组分另１１为５５．６％和８７．２％；对照组分别为１１．８％和５５．３％，治疗组疗效优于对照组（Ｐ＜０．０１）。结论：衍化四君子汤对胃粘膜肠化有良好疗效，证明了肠化是可以逆转的，为胃癌前病变和胃癌的防治开拓了新途径。

英文摘要:

To investigate the effects of Modified Sijunzi decoction (MSJZD) in treating gastric pre-cancerouslesion. Methods: Two hundreds and two patients with chronic gastritis and intestinal metaplasia (IM) of gastric mucosa diagnosed by gastroscopy and pathological examination of biopsy were divided into 2 groups, 117 cases of thetreatment group were treated with MSJZD and 85 cases of the control group were treated with Weimeisu (维酶素). For both groups, re-examination was taken after a 3-month treatment. Results: The cure rate and total effective rate of IM in the treatment group were 55. 6 % and 87. 2 % respectively, while in the control group were 11.8 % and 55. 3 % respectively (P < 0 .01 ). Conclusions: The intestinal metaplasia process of gastric mucosa is reversible and MSJZD has gall effect on it. This study provided a new way of pre-cancerous lesion treatment andgastric cancer prevention.

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