通心络胶囊对犬心脏血流动力学及心肌耗氧量的影响

观察通心络胶囊对麻醉犬心脏血流动力学及心肌耗氧量的影响。方法：经十二指肠给通心络胶囊，用多道生理记录仪分别测量冠状动脉血流量、心输出量、左室内压、左室内压上升最大速率、动脉血压及肢体标准Ⅱ导联心电图。测定心肌耗氧量等心脏血流动力学指标。结果：通心络胶囊０．７２ｇ／ｋｇ剂量组，给药后４５ｍｉｎ冠状动脉血流量增加了２１．５６％，同时增加左室作功，与生理盐水组比较有明显差异（Ｐ＜０．０１）。结论：通主络胶囊，明显增加麻醉犬冠状动脉血流量，扩张冠状动脉血管，改善心肌的供血，增加左室作功，使心脏的泵功能得以加强，血管内血液的瘀滞状态得以改善。

英文摘要:

To observe the effects of Tongxinluo (TXL) capsule on hemodynamics and myocardial oxygen consumption in dogs. Methods: The coronary arterial arterial blood flow, cardiac output, left ventricular pressure, bloodpressure, myocardial oxygen consumption of dogs were recorded by the polygraph system before and after intraduodenal administration of TXL. Results: TXL 0.72g/kg increased obviously the coronary arterial blood flow by 21.56 % after administration, and the left ventricular work was increased simultaneously, the difference was significant (P＜0. 01) as compared with the control group. Conclusions: TXL capsule could increase Obviously the coronary arterial bind flow, dilate the coronary vessels, improve myocardial blood supply, increase left ventricular work,and result in the enhancement and readjustment of the"pump"function of heart and improvement of the intravascular stasis condition of blood drculation.

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