保元强肾Ⅱ号对慢性肾功能衰竭血浆及尿SOD、MDA的影响

作者	单位
朱辟疆	江苏省中西医结合肾病研究中心
周逊	江苏省中西医结合肾病研究中心
韦先进	江苏省中西医结合肾病研究中心

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中文摘要:

目的：探讨补肾活血中药对慢性肾功能衰竭的治疗效果。方法：将４０例慢性肾功能衰竭患者随机分为保元强肾Ⅱ号组及肾安加开搏通组治疗，观察其对血浆及尿ＳＯＤ、ＭＤＡ及肾功能影响。结果：两组治前均有血浆ＳＯＤ降低及ＭＤＡ增高（Ｐ＜０．０１），尿ＳＯＤ及ＭＤＡ均呈现增高（Ｐ＜０．０１），治疗组治后血浆ＳＯＤ增高、ＭＤＡ降低，尿ＳＯＤ及ＭＤＡ均降低（Ｐ均＜０．０１），ＢＵＮ、ＳＣｒ及ＣＣｒ显著改善（Ｐ＜０．０１）。结论：保元强肾Ⅱ号片有增强抗氧化能力，抑制脂质过氧化作用，从而改善肾功能。

英文摘要:

To observe the effect of Chinese herbs of replenishing Kidney in treating chronic renal failure (CRF). Methods: Forty patients with CRF wrer randomly divided into two groups, Baoyuan Qiangshen (BQ)Ⅱtablet group and essential amino acid added capoten group.The changes of plasma and urine superoxide dismutase (SOD) and malondialdehyde(MDA)and the kidney function indices were investigated before and after treatment.Results:Before treatment, SOD reduced and MDA of both groups increased (P<0.01 ), while urine SOD and MDA increased (P<0.01). After treatment, plasma SOD increased but MDA was reduced and urine SOD, MDA were also reduced (P<0.01). Although the BUN and serum creatinine reduced significantly, creatinine clearance rate elevated significantly (P<0.01). Conclusions: The BQ Ⅱ tablet could strengthen antioxidation and inhibit lipid peroxidation, so it was effective to improve kidney function.

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