降糖康对Ⅱ型糖尿病患者血糖、血液粘度、胰岛素敏感性等指标的影响

目的：观察降糖康对Ⅱ型糖尿病患者血糖、血液粘度、胰岛素敏感性等指标的影响。方法：将初治及磺脲类药物控制不佳的Ⅱ型糖尿病患者随机分为治疗组（男５５例，女４１例）和对照组（男５３例，女３９例），保持饮食及药物不变，治疗组加降糖康８ｇ，每日３次口服，对照组初治者用优降糖，用磺脲美降糖药者保持同前。结果：治疗组用药后空腹及餐后血糖、糖化血红蛋白显著好转（Ｐ＜０．００１），血液粘度和血甘油三酯降低；对照组血糖亦改善，但血粘度、血脂无明显变化。降糖康能增高初治者血清Ｃｒ（Ｐ＜０．０１），还可使胰岛素敏感性明显提高，并可降尿微量白蛋白。结论：降糖康可显著提高患者机体对胰岛素敏感性，降低血糖，并改善血液粘度。

英文摘要:

To study the hypoglycemic effect of Jiangtangkang (JTK), a Chrysanthemum product and its influence on sensitivity of insulin in non-insulin dependant diabetes mellitus (NIDDM). Methods: Newly discovered (71 cases) and poorly controlled (117 cases) NIDDM were divided to JTK, 8 g each time, 3 times per day, and the control (Glibenclazide in newly discovered, no treatment in poorly controlled) group respectively. Results: After 2 months of treatment, the fasting blood glucose (FBG), postprandial blood glucose (PBG), glucosylated hemoglobin (GHb) improved remarkably and insulin of plasma remained unchanged in JTK group, their blood viscosity and triglyceride decreased after 6-month reatment, the FBG, PBG lowered in the control group while their viscosity and lipids were unaffected. Insulin tolerance test on newly discovered NIDDMs showed an increased sensitivity to insulin, their serum chromium elevated, and the urinary albumin in poorly controlled persons lowered significantly. Conclusions: JTK might improve the sensitivity to insulin and decrease the blood viscosity in NIDDM.

关闭