三七总皂甙改善高血压病左室舒张功能的临床与实验研究

作者	单位
冯培芳	浙江中医学院附属医院
秦南屏	浙江中医学院附属医院
乔樵	浙江中医学院附属医院
许志良	浙江中医学院附属医院

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中文摘要:

目的：研究三七总皂甙（ＴＳＰＮＳ）对高血压病（ＥＨ）左室舒张功能的影响及其可能机理。方法：测定３０例Ⅰ期ＥＨ患者联合运用ＴＳＰＮＳ和开搏通治疗前后的左室舒张功能（Ｅ峰、Ａ峰、Ｅ／Ａ、Ｅ面积分数、Ａ面积分数）、左室，Ｃ肌重量指数（ＬＶＭ）红细胞内Ｃａ２＋及其膜上Ｃａ泵活性；并以单用开搏通治疗为自身对照。同时通过对ＴＳＰＮＳ及生理盐水治疗ＳＨＲ大鼠的疗效的对比研究，以月龄相仿的ＷＫＹ大鼠为正常对照。结果：ＴＳＰＮＳ能明显改善左室舒张功能，显著提高心肌细胞内肌浆网膜上Ｃａ泵活性，减少心肌细胞内Ｃａ２＋，减轻左室心肌重量。红细胞内Ｃａ２＋及其膜上Ｃａ泵活性与心肌细胞内Ｃａ２＋及其膜上Ｃａ泵活性有显著简单相关。结论：ＴＳＰＮＳ改善左室舒张功能的机理可能与提高肌浆网膜上Ｃａ泵活性、纠正心肌细胞内ｃａ２＋超负荷及减轻左室心肌重量有关。

英文摘要:

Objective: To investigate the effect of total saponins Of Panax Notoginseng (TSPNS) on left ventricular diastolic function in patients with essential hypertension (EH) and possible mechanism. Methods: Left ventricular diastolic function (peak E, peak A, E/A, A area fraction, E area fraction), left ventricular muscle mass index (LVMI), intraerythrocytic calcium and calcium pump activity on erythrocytes membrance of 30 Patients with EH before and after the combined treatment of captopril and TSPNS were measured. Captopril was used singly on 30 patients above mentioned that were also studied as self-control. Observation of TSPNS and normal saline was used on a matched control in treating SHR rats. WKY rats of similar age were also studied as normal coned. Results: Left ventricular diastolic function were improved markedly by TSPNS. The activity of caldum pump on membrance of sarcoplasmic reticulum were increased and the myocardial intracellular calcium were decreased and the left ventricular muscle mass were reduced after treatment of TSPNS. The calcium and calcium pump of erythrocyte showed marked simple correlation with myocardial cell. conclusions: The TSPNS could improve myocardial relaxation function due to enhancing calcium pump activity and inhibiting intracellular calcium overload and lightening left ventricular muscle mass.

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