甲状腺机能亢进症用硫脲类药物致白细胞减少的中西医结合治疗

Clinical Investigation on Treatment of Integrated Traditional and Western Medicine in Hyperthyroidism with Leukocytopenia Induced by Sulfourea Drogs

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中文关键词: 甲状腺功能亢进症硫脲类药物白细胞减少

英文关键词:hyperthyroidism sulfourea drug leukocytopenia

基金项目:

作者	单位
吕维名	江西赣南医学院附属医院!江西　341000

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中文摘要:

目的：为寻求治疗甲状腺机能亢进症（简称甲亢）安全有效的药物。方法：６０例硫脲类药物所致白细胞减少的甲亢患者随机分为治疗组与对照组。其中治疗组３１例除用西药外并遵循辨证论治原则加用中药，对照组２９例单纯用西药治疗，４周后进行总疗效、主要症状、血象及免疫指标评估。结果：治疗组总有效率（９６．８％）优于对照组（８６．２％，Ｐ＜０．０５）；临床症状改善率治疗组明显优于对照组；两组患者白细胞计数均升高，但治疗组优于对照组（Ｐ＜０．０５）；甲状腺球蛋白抗体、甲状腺微粒体抗体转阴率优于对照组（Ｐ＜０．０１）。结论：中西医结合治疗因硫脲类药物所致白细胞减少的甲亢患者不但可以改善症状，升高白细胞，而且可以改善免疫功能。

英文摘要:

Objective: TO seek for a safe and effective dug to treat hyperthyroidism. Mathods: Sixty cases of hyperthyroidism with leukocytopenia induced by sulfourea drugs were divided into treatment and control groups by 31 cases who were treated by traditional medicine Syndrome differentiation and 29 cases who were treated by conventional western medicine alone respectively at random. They were estimated by total effective rate, major symptoms, WBC and immunological tests after four weeks. Results: The total effective rate in the treatment group (96.8% ) was more effective than that in the control group (86.2 %, P < 0.05 ). The symptom recovery rate in the treatment group was better than that in the control group. The WBC in both were all increased, but in the treatment group, it was better than that in the control group (P < 0.05 ). The positive to negative rate of thyroglobulin antibody and thyromicrosome antibody in the treatment group was better than that in the control group (P < 0.01 ). Conclusions: It can not only improve the symptoms and immune function, but also increase WBC by using western medicine in combination with traditional medicine in treating hyperthyroidism.

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