心脉通胶囊保护血管内皮细胞损伤的临床研究

作者	单位
丘瑞香	中山医科大学附属第一医院!广州510089
贺敬波	中山医科大学附属第一医院!广州510089
蓝军	中山医科大学附属第一医院!广州510089

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中文摘要:

探讨心脉通胶囊对冠心病心肌缺血的治疗作用。方法：３８例冠心病心肌缺血患者在常规西药治疗基础上随机分为心脉通组（２０例，加用心脉通胶囊治疗），对照组（１８例），观察治疗前后血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）含量，心电图ＳＴ段和临床症状等的变化，并与１４名健康人作对比。结果：治疗前两组冠心病心肌缺血患者ＥＴ明显高于健康人（Ｐ＜０．０１），ＣＧＲＰ变化不明显（Ｐ＞０．０５）。治疗后两组患者ＥＴ及症状计分均明显降低（Ｐ＜０．０１），ＳＴ段均明显升高（Ｐ＜０．０１），但心脉通组ＥＴ、症状计分降低及ＳＴ段上升幅度明显大于对照组（Ｐ＜０．０５～Ｐ＜０．０１）；对照组ＣＧＲＰ变化不明显（Ｐ＞０．０５），心脉通组ＣＧＲＰ明显提高（Ｐ＜０．０１）。结论：冠心病患者存在严重血管内皮损伤，心脉通胶囊能抑制血浆ＥＴ的过量释放，同时有促进血浆ＣＧＲＰ的生成和分泌作用并有良好的抗心肌缺血作用，其作用与改善血管内皮细胞功能，调整ＥＴ和ＣＧＲＰ代谢有关。

英文摘要:

To assess the effect of Xinmaitong (XMT) capsule in treating coronary heart disease (CHD). Methods: Thirty-eight patients of coronary heart disease with myocardial ischemia were divided randomly into XMT group (20 cases) and control group (18 cases). Conventional western medical therapy was given to both groups and the XMT group received additional XMT treatment. The changes of endothelin (ET) and calcitonin gene-related peptide (CGRP) levels, ST segment of ECG and clinical symptoms after treatment in all the patients were observed. Data of 14 healthy persons were taken as normal control. Results: The ET level of all patients was significantly higher than that of the normal control (P<0.001), and level of CGRP in patients was not different from normal control significantly (P>0.05). After treatment, results showed that: (1) The ET levels and the scores of clinical symptoms of both groups decreased significantly (P<0.01), and ST segment elevated markedly (P<0.01) as compared with before treatment, and the changes revealed more evident in XMT group in comparison with those of the control group (P<0. 05～P<0.01). (2) The level of CGRP was significantly increased in XMT group (P<0.01) while unchanged in the control group (P>0.05). Conclusions: There is severe damage of vascular endothelial cells in CHD patients. XMT could not only reduce significantly the plasma ET content, but also enhance markedly the production and release of CGRP, so it has a good anti-ischethec effect, which may be closely related with its action on improving the function of vascular endothelial cells and regulating metabolism of ET and CGRP.

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