雷络酯片治疗类风湿性关节炎的临床研究

作者	单位
杜秀兰	Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011
张宏	Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011
傅新利	Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011
张之澧	Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011
张梅涧	Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011
马永祯	Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011

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中文摘要:

观察雷公藤叶制剂──雷络酯片治疗类风湿性关节炎的疗效和毒副作用。方法：采用前瞻性、多中心、随机双盲对照的方法，共观察类风湿性关节炎２７７例，治疗组１４０，口服雷络酯片，每次２片，每天３次；对照组１３７例，口服雷公藤根制剂──雷公藤多甙片，每次２片，每天３次，均６周为１个疗程。结果：治疗组愈显率２５．７１％，总有效率为８６．４３％；对照组愈显率２６．２８％，总有效率为８３．９４％，两组比较无显著性差异（Ｐ＞０．０５）。不良反应的发生率治疗组为２０．００％，对照组为２３．３５％，两组比较无显著性差异（Ｐ＞０．０５）。结论：雷公藤叶制剂的有效性及安生性均同于根制剂。

英文摘要:

To observe the curative effect, toxic and side effect of Tripterygium Wilfordii Complex Ester Tablet (TWT, a preparation of Folium Tripterygium wilfordii) in treating rheumatoid arthritis. Methods: Two hundred and seventy seven patients were observed with prospective, multicentric and random double-blind control method. One hundred and forty cases of TWT group were treated with TWT 2 tablets each time, 3 times a day orally, and the other 137 cases treated with Tripterygium Wilfordii Polycoside Tablet (TPT, a preparation of Radix Tripterygium Wilfordii) 2 tablets each time were taken as control, 3 times a day orally. The therapeutic course for both groups was 6 weeks. Results: The markedly controlled rate of the TWT group was 26. 71% and the total effective rate was 86.43%, while those in the control group were 26. 28% and 83. 94% respectively, the difference between the two groups was insignificant (P>0.05). The occurrence of side-effect in the two groups was 20.00% and 23.35% respectively, also showed no significant difference (P>0.05). Conclusion: The Folium Tripterygium Wilfordii preparation is similar in efficacy and security to the Radix Tripterygium Wilfordii preparation.

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