764-3对不同类型慢性肺动脉高压大鼠右心室肥厚胶原的影响

作者	单位
柳志红	Liu Zhihong, Cheng Xiansheng, Cai Rusheng, et al (Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Magical College, Beijing (100037
程显声	Liu Zhihong, Cheng Xiansheng, Cai Rusheng, et al (Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Magical College, Beijing (100037
蔡如升	Liu Zhihong, Cheng Xiansheng, Cai Rusheng, et al (Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Magical College, Beijing (100037
朱宜明	Liu Zhihong, Cheng Xiansheng, Cai Rusheng, et al (Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Magical College, Beijing (100037
李亚辉	Liu Zhihong, Cheng Xiansheng, Cai Rusheng, et al (Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Magical College, Beijing (100037
李群	Liu Zhihong, Cheng Xiansheng, Cai Rusheng, et al (Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Magical College, Beijing (100037

摘要点击次数: 1367

全文下载次数: 965

中文摘要:

观察胶原合成抑制剂７６４－３对低压缺氧和野百合碱（ＭＣＴ）引起的肺动脉高压大鼠右心室胶原的影响。方法：将雄性Ｗｉｓｔａｒ大鼠随机分为１０组。低压缺氧给药组大鼠皮下注射７６４－３２０ｍｇ／ｋｇ，每日１次；ＭＣＴ治疗组大鼠皮下注射７６４－３４０ｍｇ／ｋｇ，每日１次。实验终点测定血流动力学及生化指标。结果：缺氧２周，４周及ＭＣＴ大鼠肺动脉压升高，右心室胶原含量明显增加；７６４－３能降低缺氧及ＭＣＴ大鼠肺动脉压，减少缺氧２周及ＭＣＴ大鼠右室胶原含量（μｇ），分别由７６．３±１３．３降至５９．４±１１．４（Ｐ＜０．０１），２９３．４±７３．９降至２１０．１±３７．６（Ｐ＜０．０１）。结论：７６４－３对缺氧性肺动脉高压大鼠右室胶原沉积仅有部分预防作用，对ＭＣＴ大鼠的右室肌胶原沉积有治疗作用。

英文摘要:

To observe the effect of 764-3 on ventricular collagen deposition in pulmonary hypertension induced by chronic hypoxia or monocrotaline (MCT) in rats. Methods: Wistar rats were divided into 10 groups. The hypobaric hypoxia group received 764-3 20mg/kg once daily subcutaneously and the MCT group treated with 764-3 40mg/kg once daily. The hemodynamic and biochemical parameters were measured. Results: At the time of 2 weeks and 4 weeks after treated with hypoxia or MCT, the pulmonary arterial pressure (PAP) of rats raised significantly and the right ventricular collagen content (RVCC) increased markedly. 764-3 could reduce the raised PAP induced either by hypoxia or MCT. It could lower the elevated RVCC of hypobaric hypoxia group at 2 weeks from 76.3± 13.3 to 59.4±11.4 (P<0. 01), and the RVCC of MCT group lowered from 293.4±73.9 to 210.1± 37.6(P<0.01), Conclusion: 764-3 could partially prevent right ventricular collagen deposition induced by hypox ia and has therapeutic effect on that induced by MCT.

关闭