人工麝香保心丸治疗冠心病心绞痛112例临床观察

作者	单位
王受益	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
戴瑞鸿	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
金椿	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
徐济民	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
郑慧君	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
陈曙霞	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
陈美芳	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
胡婉英	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040
乐国祥	Wang Shouyi, Dai Ruihong, Jin Chun, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040

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中文摘要:

目的 :为验证人工麝香保心丸治疗冠心病心绞痛的作用。方法 :将 2 2 5例冠心病心绞痛患者 ,随机、双盲分为治疗组 (1 1 2例 )和对照组 (1 1 3例 )。分别给予人工麝香保心丸、天然麝香保心丸各 2丸 ,每日 3次口服。结果 :经 2周治疗 ,两药均可显著降低心绞痛发作频率 ,硝酸甘油日耗量 ,并显著改善心电图NST ,∑ST及运动耐量 ,显著降低心率收缩压乘积RPP)。总的症状疗效 ,分别为 86 6%、89 4% (P >0 0 5 ) ,心电图疗效 5 2 7%、5 7 5 % (P >0 0 5 ) ;头痛发生各 1例。此外两药均起效迅速 ,分别有 88 5 %与 78 6%在 5min内生效 ,持效时间为 4 9± 4 4h、5 4± 3 1h(P >0 0 5 ) ,亦基本相仿。结论 :人工麝香保心丸治疗冠心病心绞痛疗效和不良反应与天然麝香保心丸相仿。

英文摘要:

Objective: To test and verify the effect of artificial Shexiang Baoxin Pill (SXBXP, a heart protecting musk pill). Methods: Two hundred and twenty five patients of coronary heart disease (CHD) with angina pectoris were randomly and blindly assigned to the study group (112 cases) and the control group (113 cases). The two groups were well matched in age, sex, angina type, complication and grade of cardiac function. Two pills of artificial or natural SXBXP were given to each cases of the two groups for 3 times every day orally, for 2 weeks, respectively. Results: Both the artificial and natural SXBXP could not only reduce significantly the frequency of angina episode and the daily consumption of nitroglycerin, they also could result in remarkable improvement of NST, ∑ST and exercise tolerance, as well as significant reduction of rate pressure product. The total symptomatic effective rate of the two groups was 86 6% and 89 4% respectively, and the ECG effective rate, 52 7% and 57 5% respectively (P>0 05), and the incidence of headache of the two groups was one for eoch. In addition, the onset of action of both agents was rapid, 88 5% of the study group and 78 6% of the control group were within five minutes. The sustained time of action of the two groups was also similar, i.e. 4.9±4.4h vs 5.4±3.1h. Conclusion: The clinical efficacy and side effect of artificial SXBXP were very similar to those of natural SXBXP.

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