川芎嗪治疗胎儿宫内生长迟缓中氧自由基与血栓素B<sub>2</sub>、6-酮-前列腺素<sub>1α</sub>的相关性研究

作者	单位
许建平	同济医科大学附属同济医院妇产科!武汉430030
马庭元	同济医科大学附属同济医院妇产科!武汉430030
闻良珍	同济医科大学附属同济医院妇产科!武汉430030

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中文摘要:

目的 :探讨胎儿宫内生长迟缓 (IUGR)的病理生理改变及有效治疗方法。方法 :5 8例患者分为川芎嗪组 (47例 )和氨基酸组 (1 1例 ) ,分别给予治疗 ,并测定了 85名正常妊娠者及本病患者的有关指标。结果 :IUGR者母血脂质过氧化物 (LPO)异常增高 ,而SOD、谷胱甘肽过氧化物酶 (GSH Px)活力及 6 酮前列腺素1α(6 keto PGF1α)水平显著下降 ,血栓素B2(TXB2 ) / 6 keto PGF1α比值增高 ,该比值与SOD、GSH Px活力呈负相关 ,与LPO水平呈正相关(P <0 0 1 ) ;治疗后上述变化可接近或恢复正常 ;总有效率川芎嗪组 (95 7% )显著高于氨基酸组 (81 8% ,P <0 0 5 )。结论 :IUGR者体内氧化 /抗氧化系统平衡紊乱 ,子宫胎盘胎儿血液循环障碍 ;川芎嗪可抑制氧自由基的生成并增强SOD和GSH Px活力 ,调节TXA2 /PGI2 平衡 ,促进胎儿生长。

英文摘要:

Objective: To study the pathophysiological changes and effective treatment of intrauterine growth retardation (IUGR). Methods: Eighty five cases with normal pregnancy and 58 IUGR women maternal red blood cell superoxide dismutase (SOD), glutathione peroxidase (GSH Px), serum lipid peroxide (LPO) and thromboxane B 2 (TXB 2),6 keto PGF 1α (6KP) were examined. IUGR group was divided into Ligustrazine group (LIG, 47 cases) and amino acid group (AAG, 11 cases) and treated accordingly. Results: In IUGR group, LPO increased and SOD, GSH Px activity, 6KP value decreased abnormally, TXB 2/6KP ratio significantly increased, which was negative correlated with SOD, GSH Px activity and positive correlated with LPO level markedly. After treatment, all the changes were improved and almost reached normal range. The fetal outcome showed that the total effective rate was 95.7% in LIG, markedly higher than that in AAG (81.8%, P<0 05), there was significant difference between LIG and AAG. Conclusions: The balance of body oxidate/antioxidate system was disturbed and the uteroplacental fetal circulation was obstracted in IUGR. Ligustrazine could inhibite oxygen free radical, rise SOD, GSH Px activity, regulate TXA 2/PGI 2 balance, promote fetal growth.

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