葛根素治疗不稳定性心绞痛的临床研究

作者	单位
赵志明	湖北医科大学附属第一医院老年病科!武汉430060
杨晓英	湖北医科大学附属第一医院老年病科!武汉430060
张永珍	湖北医科大学附属第一医院老年病科!武汉430060
肖正益	湖北医科大学附属第一医院老年病科!武汉430060

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中文摘要:

目的 :观察葛根素注射液治疗不稳定性心绞痛 (UA)的临床疗效。方法 :分别观察葛根素组 (2 1例 )、对照组 (1 8例 )治疗前后的心绞痛发作频率 ,硝酸甘油用量 ,静息心电图 ,血压 ,心率及心肌耗氧量的变化。结果 :葛根素组在减少心绞痛发作 ,降低硝酸甘油用量 ,改善异常心电图方面优于对照组 (P <0 0 5 ) ,心肌耗氧量也明显减少 (P <0 0 5 )。结论 :葛根素治疗UA效果肯定 ,副作用小 ,值得临床推广应用。

英文摘要:

Objective: To observe the clinical efficacy of puerarin in treating patients with unstable angina (UA). Methods: Frequency of angina events, consumed doses of nitrates, heart rate, blood pressure, rest electrocardiogram (ECG) and myocardial oxygen consumption were observed before and after drug therapy in puerarin group (21 cases) and control group (18 cases) respectively. Results: The puerarin group not only showed more effective than that in control group in reducing frequency of angina events and consumed doses of nitrates and improving abnormal rest ECG, but also appeared to be preferable to the control group in reducing myocardial oxygen consumption and increasing exercise duration (P<0 05). Conclusion: Puerarin is a safe and effective drug in treating patients with UA.

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