中风脑得平冲剂对卒中型自发性高血压大鼠出血性中风海马兴奋性氨基酸和神经元的影响

Effect of Zhongfeng Naodeping Granule on Hippocampal Excitatory Amino Acid and Neuron of Stroke-Prone Spontaneously Hypertensive Rats with Hemorrhagic Apoplexy

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中文关键词: 中风脑得平冲剂卒中型自发性高血压大鼠海马兴奋性氨基酸形态学

英文关键词:Zhongfeng Naodeping Granule stroke prone spontaneously hypertensive rats hippocampus excitatory amino acid morphology

基金项目:八五国家科技攻关资助项目!(No 85 - 919- 0 2 - 0 1)

作者	单位
蒋玉凤	北京中医药大学病理教研室!北京100029
朱陵群	北京中医药大学病理教研室!北京100029
黄启福	北京中医药大学病理教研室!北京100029
邹丽琰	北京中医药大学病理教研室!北京100029
李伯光	北京中医药大学病理教研室!北京100029
严京	北京中医药大学病理教研室!北京100029

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中文摘要:

目的 :观察中风脑得平冲剂对出血性中风的保护作用。方法 :采用卒中型自发性高血压大鼠 (SHRsp) ,检测海马区兴奋性氨基酸 (EAA)含量以及CA1 区神经元的病理改变。结果 :中风脑得平冲剂可明显降低SHRsp出血性中风海马区谷氨酸 (Glu)和天门冬氨酸 (Asp)的含量 (P <0 0 5～ 0 0 1 ) ;海马CA1 区神经元损伤程度轻 ;光镜显示神经元密度显著增加 (P <0 0 1 ) ;超微结构显示脑组织水肿、变性和坏死均得到明显改善。结论 :中风脑得平冲剂对SHRsp出血性中风神经元有保护作用 ,可能与降低EAA的含量有关。

英文摘要:

Objective: To observe the effects of Zhongfeng Naodeping Granule (ZFNDPG) on hemorrhagic apoplexy. Methods: The stroke prone spontaneously hypertensive rats (SHRsp) were used to study effects of ZFNDPG on hemorrhage apoplexy. Excitatory amino acid (EAA) concentration in hippocampus sector, neuronal density and ultrastructural changes in hippocampal CA 1 sector were measured. Results: In pathological model group glutamate (Glu) and aspartate (Asp) concentration elevated obviously. With the ZFNDPG treating SHRsp of hemorrhagic apoplexy, Glu and Asp concentration in hippocampal sector could be markedly inhibited, compared with model group, P<0 05～0 01. Neuronal morphology was observed: neurone injury was mild and neuronal density increased in hippocampal CA 1 sector of treatment group, compared with model group, P<0 01. Electron microscopy showed: edema, degeneration and necrosis caused by hemorrhagic apoplexy were improved after the ZFNDPG treatment. Conclusions: Effects of protecting neurone for SHRsp on hemorrhagic apoplexy might be associated with that ZFNDPG inhibited concentration of EAA.

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