川芎嗪对先天性心脏病肺动脉高压体外循环下血栓素A<sub>2</sub>及前列环素的影响

作者	单位
黄瑞健	Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005
廖崇先	Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005
陈道中	Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005
陈为民	Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005
翁钦永	Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005

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中文摘要:

目的 :探讨川芎嗪对先天性心脏病肺动脉高压患者体外循环下血栓素A2(TXA2 ) /前列环素 (PGI2 )平衡的保护作用。方法 :将 3 0例非紫绀型先天性心脏病肺动脉高压患者随机分为对照组 (1 5例 )和用药组 (1 5例 )。川芎嗪分别于麻醉诱导后静脉滴注 3mg/kg及转流后加入氧合器中 1mg/kg ,分别于麻醉诱导后、转流 1 5min、升主动脉开放 5min、停机后2 0min、6h及 2 4h采血并测定TXA2 、PGI2 。结果 :用药组与对照组比较 ,除术前、停机后 2 4h外 ,其余各时点均有显著性差异 (P <0 0 1 )。结论 :川芎嗪能纠正先天性心脏病肺动脉高压患者体外循环下TXA2 、PGI2 的失衡。

英文摘要:

Objective: To study protective effects of tetramethylpyrazine (TMP) on the imbalance of TXA 2/PGI 2 during cardiopulmomary bypass (CPB) in congenital heart disease (CHD) with pulmonary hypertension (PH) patients. Methods: Thirty patients suffered from non cyanotic CHD PH were randomly divided into control group (n=15) and treatment group (n=15). 3 mg/kg of TMP was dripped intravenously after anesthesia and 1 mg/kg of TMP was infused into oxygenator after CPB individually. Blood samples were collected and TXA 2 as well as PGI 2 were measured after anesthesia induction, 15 min during CPB, 5 min after release of the aortic cross clamp,and 20 min, 6 hrs and 24 hrs after CPB. Results: There was significant difference between treatment group and control group except before operation and 24 hrs after CPB. Conclusions: The imbalance of TXA 2 and PGI 2 in patients with CHD PH during CPB could correct by TMP.

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