高血压病左心室肥厚患者血浆P物质水平的变化及活血祛痰治法的影响

Study on Changes of Plasma Substance P in Essential Hypertension with Left Ventricular Hypertrophy Patients and the Effect of Promoting Blood Circulation and Eliminating Phlegm

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DOI：

中文关键词: 高血压病左心室肥厚血浆P物质活血祛痰法

英文关键词:essential hypertension left ventricular hypertrophy plasma substance P promoting blood circulation and eliminating phlegm

基金项目:

作者	单位
严灿	Yan Can, Gao Min, Deng Zhongyan, et al Basic Medical College, Guangzhou University of TCM, Guangzhou (510407
高敏	Yan Can, Gao Min, Deng Zhongyan, et al Basic Medical College, Guangzhou University of TCM, Guangzhou (510407
邓中炎	Yan Can, Gao Min, Deng Zhongyan, et al Basic Medical College, Guangzhou University of TCM, Guangzhou (510407
严序炳	Yan Can, Gao Min, Deng Zhongyan, et al Basic Medical College, Guangzhou University of TCM, Guangzhou (510407
吴丽丽	Yan Can, Gao Min, Deng Zhongyan, et al Basic Medical College, Guangzhou University of TCM, Guangzhou (510407

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中文摘要:

目的 :探讨血浆P物质 (SubstanceP ,SP)与高血压病左心室肥厚的关系以及活血祛痰治法对其影响。方法 :采用放射免疫法检测高血压病左心室肥厚 (EH LVH)患者用活血祛痰法治疗前后血浆SP水平的变化 ,同时检测EH LVH患者治疗前后左心室重量指数 (LeftVentricularMassIndex ,LVMI)、平均动脉压 (MeanAteriallPressure,MAP)、血浆肾素活性(PlasmaReninActivity,PRA)及血管紧张素Ⅱ (AngiotensinⅡ ,AngⅡ )浓度等的变化。结果 :EH LVH患者血浆SP水平显著下降 ,与高血压无左心室肥厚患者及健康人组比较有显著性差异 (P <0 0 0 1 ) ;PRA及AngⅡ浓度明显高于健康人组 (P <0 0 1 )。经活血祛痰法治疗后 ,EH LVH患者血浆SP含量升高 ,LVMI、MAP、PRA及AngⅡ浓度降低 (P <0 0 1或P <0 0 5 )。治疗前后血浆SP含量与LVMI、MAP、PRA及AngⅡ之间呈显著负相关 (P <0 0 1 ) ,而LVMI与PRA及AngⅡ之间则呈显著正相关 (P <0 0 1 )。结论 :SP可能参与了高血压病左心室肥厚的发病机制 ;活血祛痰法逆转高血压病左心室肥厚的作用机理与其升高SP水平有关。

英文摘要:

Objective: Exploring the relationship between the plasma substance P(SP) and essential hypertension with left ventricular hypertrophy (EH LVH) and the effect of promoting blood circulation and eliminating phlegm. Methods: Before and after treatment, the changes of SP in patients with EH LVH were measured by radioimmunoassay. Meanwhile, the changes of plasma renin activity (PRA), angiotension Ⅱ(Ang Ⅱ), left ventricular mass index (LVMI) and mean arterial pressure (MAP) were measured. Results: The level of plasma SP in patients with EH LVH was markedly lower than that of patients without EH NLVH and healthy subjects (P<0 001); the levels of PRA and Ang Ⅱ were higher than those in control group (P<0 01 or<0.05). After treatment, the level of SP was significantly increased, while LVMI, MAP, PRA and Ang Ⅱ were significantly decrease (P<0 01 or<0.05). The levels between SP and LVMI, MAP, PRA, Ang Ⅱ were markedly negative correlated (P<0 01) while levels between LVMI and PRA, Ang Ⅱ were markedly positive correlated.Conclusions: The SP may be involved in the pathogenesis of EH LVH; the mechanism of promoting blood circulation and eliminating phlegm reversing LVH might be related to its increasing the plasma SP.

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