智灵汤治疗老年血管性痴呆临床研究

作者	单位
阎乐法	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
刘百波	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
李光宗	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
李义清	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
高汉义	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
郭文君	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
王梅	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
崔华勤	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042
孙鲁妍	Yan Lefa, Liu Baibo, Li Guangzong, et al Weifang Medical College, Shandong (261042

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中文摘要:

目的 :观察智灵汤治疗老年血管性痴呆 (vasculardementia,VaD)的临床疗效。方法 :78例老年VaD患者随机分为治疗组与对照组。治疗组采用自拟验方智灵汤治疗 ,对照组给以脑复康治疗。结果 :智灵汤可以显著降低患者血清胆固醇 (Tch)、甘油三酯 (TG)、血浆脂质过氧化物 (LPO)含量 ;提高高密度脂蛋白 (HDL)、红细胞超氧化物歧化酶 (SOD)含量 ;扩张脑血管 ,增加脑血流灌注 ;对反映脑智能的P3 0 0检查 ,P3潜伏期缩短 ,P3波幅增高 ;脑电地形图好转 ,修改的长谷川痴呆量表 (HDS)积分提高 ,临床症状显著改善 ,临床总有效率达 87 0 %。结论 :智灵汤对老年VaD确有较好的治疗作用。

英文摘要:

Objective: To observe clinical effects of Zhiling Decoction (ZLD) in treating senile vascular dementia. Methods: Seventy eight patients were randomly divided into treated group and control group. In treated group which was treated with ZLD, a self formulated proved recipe. In control group, which was administered with Naofukang(脑复康). Results: ZLD could decrease the level of serum cholesterol, serum triglyceride and plasma LPO significantly; increase the level of high density lipoprotein (HDL) and SOD in red blood cells; dilate cerebral vessels, increase cerebral blood flow. As for P300, an index to reflect intelligence, the latency of P 3 was shorter and the amplitude was raised, the brain electrical activity monitoring (BEAM) was improved remarkably, the revised Nagayakawa dementia scale scoring (NDS) of patients promoted, clinical symptom was improved significantly. Total effective rate in clinical practice reached 87%. Conclusion: ZLD had good effects on senile vascular dementia indeed.

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