中西医结合治疗小鼠柯萨奇B<sub>3</sub>病毒性心肌炎的实验研究

作者	单位
熊丁丁	Xiong Dingding, Yang Yingzhen ,Su Yangang, et al Ministry of Health Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital of Shanghai Medical University, Shanghai (200032
杨英珍	Xiong Dingding, Yang Yingzhen ,Su Yangang, et al Ministry of Health Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital of Shanghai Medical University, Shanghai (200032
宿燕岗	Xiong Dingding, Yang Yingzhen ,Su Yangang, et al Ministry of Health Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital of Shanghai Medical University, Shanghai (200032
胡英	Xiong Dingding, Yang Yingzhen ,Su Yangang, et al Ministry of Health Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital of Shanghai Medical University, Shanghai (200032
陈灏珠	Xiong Dingding, Yang Yingzhen ,Su Yangang, et al Ministry of Health Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital of Shanghai Medical University, Shanghai (200032

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中文摘要:

目的 :观察中西医结合治疗小鼠柯萨奇B3(CVB3)病毒性心肌炎 (VMC)的疗效。方法 :腹腔接种CVB3病毒液以建立VMC模型。随机等分为对照、黄芪、牛磺酸和辅酶Q1 0 (CoQ1 0 )单独用药组及黄芪分别加牛磺酸、CoQ1 0 治疗组以及三药联合治疗组。观察 7组在死亡率、心电图、心肌中CVB3RNA含量及心肌形态学改变差别。结果 :黄芪联合牛磺酸和CoQ1 0 治疗可明显降低小鼠的死亡率及急性期异常心电图的发生率 ;黄芪具有一定的抗病毒能力 ,联合牛磺酸后抗病毒能力增强。而CoQ1 0 则无明显抗病毒作用 ;三种药物均可减轻心肌的病变程度 ,尤以三药联合的作用为好。结论 :黄芪、牛磺酸和CoQ1 0 对VMC小鼠均有一定的疗效 ,联合使用可使疗效增强。

英文摘要:

Objective: To clarify the effects of Astragalus Membranaceus (AM) combined with taurine and/or coenzyme Q 10 (CoQ 10 ) on coxsackievirus B3 (CVB 3)murine myocarditis. Methods: Viral myocarditis model was created by intraperitoneal inoculation with CVB 3 solution and were treated by saline, AM, taurine, CoQ 10 , AM+taurine, AM+CoQ 10 , AM+taurine+CoQ 10 , respectively. The mortality, ECG, CVB 3 RNA in myocardium and myocardial histopathologic changes were observed. Results: AM combined with taurine and CoQ 10 could significantly reduce the mortality of the mice and the incidence of abnormal ECG at acute stage. CVB 3 RNA was significantly reduced in AM treated group, especially in AM+taurine group. No anti virus effect was found in CoQ 10 group. All drugs could lighten myocardial histopathologic changes and the effect could be enhanced by combined treatment. Conclusions: AM, taurine and CoQ 10 have some curative effects on CVB 3 murine myocarditis, AM combined with taurine and CoQ 10 is the best.

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