扶正保真汤对恶性肿瘤放、化疗增效作用的临床与实验研究

作者	单位
李京	Li Jing, Li Xinqun, Li Jiabang, et al Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha (410008
黎杏群	Li Jing, Li Xinqun, Li Jiabang, et al Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha (410008
李家邦	Li Jing, Li Xinqun, Li Jiabang, et al Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha (410008
梁清华	Li Jing, Li Xinqun, Li Jiabang, et al Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha (410008
向跃前	Li Jing, Li Xinqun, Li Jiabang, et al Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha (410008
袁君	Li Jing, Li Xinqun, Li Jiabang, et al Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha (410008
唐利立	Li Jing, Li Xinqun, Li Jiabang, et al Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha (410008

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中文摘要:

目的 :探讨扶正保真汤对恶性肿瘤放、化疗的增效作用机理。方法 :1 1 7例恶性肿瘤患者予化疗或 (和 )放疗 ,其中 55例加扶正保真汤治疗 (A组 ) ,与 30例加贞芪扶正冲剂治疗(B组 )及 32例单纯放、化疗 (C组 )比较 ,并进行对荷瘤小鼠化疗增效机理研究。结果 :临床近期有效率 (CR +PR) :A、B、C组依次分别为 6 3 6 %、43 3%、37 5% ,以A组为佳 (P <0 0 5) ;生存质量亦以A组为佳 (P <0 0 5) ;治疗后患者外周血象、T细胞亚群、自然杀伤细胞活性及白细胞介素 -2以A组增高显著 (P <0 0 5或P <0 0 1 )。动物实验结果证实扶正保真汤有增强化疗药物抑制肿瘤生长作用 (P <0 0 1 ) ,升高瘤组织内cAMP ,而提高cAMP/cGMP比值 (P <0 0 1 ) ,增加G0 +G1 期细胞 ,减少S期细胞 (P <0 0 1 )。结论 :扶正保真汤通过增强免疫及造血机能 ,升高cAMP/cGMP比值 ,阻滞瘤细胞于G0 /G1 期 ,而抑制肿瘤生长 ,增强放、化疗疗效

英文摘要:

objective To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy, 55 cases treated together with FZBZD( group A), comparing with 30 cases treated with radio and chemotherapy plus Zhenqi Fuzheng Granules (group B) and 32 cases radio and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy on transplanted human lung adenocarcinoma (SPC A 1) and sarcoma (S 180 ) bearing mice was conducted. Results: Effective rates (CR+PR) of group A, B, C were 63.6%,43.3%,37.5% respectively ,that of group A was the best (P<0 05). The survival quality of life was improved best in group A (P<0 05). After being treated, the level of the peripheral blood (WBC, Hb, PLT) of group A was the highest (P<0 05); CD 3, CD 4, NK activity, interleukin 2 were also improved significantly in group A (P<0 01). Animal experiment showed that FZBZD could improve chemotherapy effect of inhibitory action on tumor growth (P<0 01), increase cAMP/cGMP ratio (P<0 01) by adding cAMP level in cancer tissue, and enhance of G 0/G 1 phase cells and decrease S phase cells. Conclusions: FZBZD inhibited tumor growth and enhanced the effect of radio and chemotherapy by improving immune and hematopoietic function, cAMP/cGMP ratio and stagnating tumor cells in G 0/G 1 phase.

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